头风愈滴丸对偏头痛大鼠血中血管活性物质的影响  

Influence of Toufengyu Dropping Pill on vasoactive substances in migraine rat

作　　者：李佳川[1] 孟宪丽[1] 曾勇[1] 张艺[2] 缪舒益[1] 

机构地区：[1]成都中医药大学药学院,四川成都611137 [2]成都中医药大学民族医药学院,四川成都611137

出　　处：《中成药》2009年第11期1666-1669,共4页Chinese Traditional Patent Medicine

基　　金："十一五"国家科技支撑计划(2006BAI06A18-15)

摘　　要：目的:观察头风愈滴丸(川芎、白芷等)对偏头痛大鼠血中神经肽及血管活性物质的影响。方法:采用硝酸甘油致大鼠偏头痛模型,观察头风愈滴丸对大鼠行为学表现以及血中NO、CGRP、ET、TXB2和6-keto-PGF1 a等血管活性物质的影响。结果:头风愈滴丸能明显减少动物的阳性反应次数,降低模型大鼠血清中NO的含量,降低血浆中CGRP、TXB2、6-ke-to-PGF1 a的含量,升高血浆中ET的含量,并纠正ET/NO比值的平衡失调。结论:头风愈滴丸通过影响神经递质、神经肽,减少致痛致炎物质、血管活性物质的释放,缓解神经源性炎症,提高机体痛阈值,缓解或预防偏头痛的发生。AIM ： To observe the influence of Toufengyu Dropping Pill （ Rhizome chuanxiong, Radix angelicae dahuricae, etc） on neuropeptide and vasoactive substances in rat＇ s migraine model. METHODS ： Rat＇ s migraine model caused by nitroglycerin were given Toufengyu Dropping Pill and rat＇ s behavior and blood levels of NO, CGRP, ET, TXB2 and 6-keto-PGFla were measured. RESULTS ： The experimental results showed that Toufengyou Dropping Dill could obviously decrease rat＇ s positive reaction number, the blood levels of NO, CGRP, TXB2 and 6-keto-PGF1a, and increase the blood plasma level of ET, and rectify the imbalance of ET/NO ratio. CONCLUSION ： Toufengyou Dropping Pill can affect the contents of neurotransmitter, neuropeptide in rat＇ s migraine, then decrease the algoenic and inflammatory substances, relieve the neurogenic inflammation, and increase the pain threshold value, finally be quite effective for migraine.

关 键 词：头风愈滴丸 偏头痛 神经肽 血管活性物质 大鼠 

分 类 号：R285.6[医药卫生—中药学]