莱菔子炮制前后成分群变化的初步研究  

Preliminary study of components group change between before and after processing Semen Raphani

作　　者：任涛[1] 吕文海[1] 张欣[2] 贾京京[1] 

机构地区：[1]山东中医药大学,山东济南250355 [2]中国药科大学,江苏南京210009

出　　处：《中成药》2009年第11期1715-1718,共4页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金资助项目(30672665)

摘　　要：目的:探讨炮制对莱菔子饮片中成分群的影响。方法:通过不同制备方法莱菔子供试样品HPLC图谱的比较和相似度计算,分析其成分群的变化规律。结果:发现莱菔子炒制具有抑制酶解机制,确认了能够产生新化合物A209、B221的前体物质C3。结论:莱菔子炮制可通过影响煎煮过程使生、炒品煎出成分不同而产生不同的临床疗效。AIM： To explore the effects of processing on components group of Semen Raphani. METHODS： By comparing HPLC maps of Semen Raphani samples prepared with different methods and computing similarity, analysis the change law of the components group. RESULTS ： The mechanism of inhibiting the enzyme by processing Semen Raphani was found and C3 was able to produce new compounds A209, B221. CONCLUSION： Processing Semen Raphani can change the components group through influencing the decoction process, eventually produce different clinical effects.

关 键 词：莱菔子 炮制 成分群 高效液相色谱 

分 类 号：R283[医药卫生—中药学]