抗植入式高分子医用材料感染的研究进展  

Recent Advances in the Anti-infection Induced by Polymer Medical Material Implants

作　　者：李春艳[1,2] 单丽[1] 出端艳[1] 黄剑华[2] 温志国[2] 董声雄[2] 

机构地区：[1]福建医科大学药学院,福州350108 [2]福州大学化学化工学院,福州350108

出　　处：《高分子通报》2009年第11期57-61,共5页Polymer Bulletin

基　　金：福建省科技厅国际合作处重点项目(2006I0019);福建省科技厅资助省属高校项目(2008F50502)资助

摘　　要：植入式高分子医用材料表面会粘附细菌形成生物膜引发生物材料相关的感染(BRI),给高分子医用材料的广泛应用提出了重大挑战。本文从BRI发生的机制入手,综述了通过高分子医用材料表面改性减少细菌粘附与使用抗菌素-生物材料体系两个方面来抵抗BRI发生的研究进展,重点阐述了局部抗菌药物缓释体系及纳米技术在抗菌药物缓释体系中的应用,并指出高分子前药控释体系的研究和应用是抗高分子医用材料感染的发展趋势。The surface of polymer medical material implants adsorbs bacteria to form biofilm lead to biomaterial related infection （BRI） represent a significant challenge to the application of polymer medical material. This paper introduced BRI mechanism, summarized the research of surface modification to reduce bacterial adhesion and antibacterial- biomaterial system. The recent advances of these two methods resistant the occurrence of BRI. Emphasize on local antibacterial sustained- release system and the application of nanotechnology in antibacterial sustained- release system. The research and application of polymer prodrug controlled-release system is the tendency of anti-infective polymer medical material.

关 键 词：高分子医用材料 抗感染 表面改性 抗菌药物缓释体系 高分子前药控释体系 

分 类 号：R318.08[医药卫生—生物医学工程]