一种新血管粘接吻合内置支架的制备及其密封原理  

Manufacture and Theory of a New Kind of Intravascular Soluble Hollow Stent for Vascular Anastomosis with Adhesive, Cyanoacrylate Glue

作　　者：范恒华[1] 伍骥[1] 张伯勋[2] 

机构地区：[1]空军总医院骨科,北京100142 [2]解放军总医院骨科医院,北京100084

出　　处：《医疗卫生装备》2009年第11期1-3,共3页Chinese Medical Equipment Journal

基　　金：北京市首都医学科学发展基金项目(2005-3094);国家自然科学基金项目(30100186)

摘　　要：目的:制备一种新的血管粘接吻合内置支架,探讨其密封原理。方法:参照化工密封原理,利用CaCl2、聚乙二醇(PEG)和明胶制备血管吻合内置中空可溶性支架(明胶CaCl2被覆中空支架,简称CaCl2中空支架),置入管腔后,对合两端,按照顺序分别滴入海藻酸钠凝胶溶液、CaCl2溶液和医用胶(氰基丙烯酸酯),医用胶浸润固化后,即完成血管粘接吻合。结果:CaCl2中空支架不仅在血管吻合中支持血管,而且可以双面成膜,增加密封厚度,加强密封效果,能够有效阻隔医用胶对吻合口和管壁的毒性作用。结论:明胶CaCl2被覆中空支架可以双面成膜,能有效提高密封效果,从而在不影响吻合口愈合的前提下,有望提高血管粘接吻合通畅率。Objective To research and make one kind of intravascular soluble hollow stent for vascular anastomosis. Methods According to the chemical industry, CaCl2, polyethylene glycol （PEG）and gelatin were used to make one kind of intravascular soluble hollow stent for vascular anastomosis, whose surface was covered with CaCl2 membrane（CaCl2 hollow stent）. After putting the stent into the two cut sides of vascular, the author put the two sides together, and dropped alginic acid sodium solution, CaCl2 solution, and glue respectively. As soon as the glue solidified, the anastomosis was finished. Results The CaCl2 hollow stent could not only support the cannel of vascular, but also generate two membrane in the two side of anastomosis site. Thus the thickness of sealant was increased. It was effective to prevent leaking of cyanoacrylate glue and its toxicity. Conclusion The CaCl2 hollow stent can generate two membrane in the two side of anastomosis site, and could increase seal effectively. Using this stent could improve the anastomosis patency by increasing the sealant thickness, and preventing leakage of cyanoacrylate glue and its toxicity.

关 键 词：吻合 密封胶(剂) CACL2 血管内置中空支架 成膜 粘接 

分 类 号：R318.0[医药卫生—生物医学工程]