叶酸卟啉化合物的合成  

Synthesis of folate-porphyrin compound

作　　者：刁俊林[1] 李东红[1] 

机构地区：[1]创伤烧伤复合伤国家重点实验室第三军医大学大坪医院野战外科研究所二室,重庆400042

出　　处：《化学研究与应用》2009年第11期1575-1577,共3页Chemical Research and Application

摘　　要：In order to obtain a molecular-targeting photosensitizer mediated by folate receptor,5-p-(4-aminobutoxyphenyl)-10,15,20-tri-p-methoxyphenylporphyrin was synthesized with a four-step procedure starting from p-hydroxybenzaldehyde,p-methoxybenzaldehyde and pyrrole,then,a novel folate-porphyrin compound was prepared through a condensation reaction of the aminoporphyrin with actived folic acid.Its structure was characterized by IR,UV-Vis,MS and 1HNMR spectra.In order to obtain a molecular-targeting photosensitizer mediated by folate receptor,5-p-（4-aminobutoxyphenyl）-10,15,20-tri-p-methoxyphenylporphyrin was synthesized with a four-step procedure starting from p-hydroxybenzaldehyde,p-methoxybenzaldehyde and pyrrole,then,a novel folate-porphyrin compound was prepared through a condensation reaction of the aminoporphyrin with actived folic acid.Its structure was characterized by IR,UV-Vis,MS and 1HNMR spectra.

关 键 词：卟啉 叶酸 靶向光敏剂 合成 

分 类 号：O622.6[理学—有机化学]