蔗糖铁注射液联合红细胞生成素治疗肾性贫血的临床观察  

Intravenous iron sucrose combined with erythropoiesis in the treatment of renal

作　　者：刘艳姝[1] 张英萍[2] 张浩[1] 刘中柱[1] 李振海[1] 

机构地区：[1]佳木斯大学附届第一医院肾内科,154003 [2]佳木斯中心医院心内科

出　　处：《国际移植与血液净化杂志》2009年第6期16-18,共3页International Journal of Transplantation and Hemopurification

摘　　要：目的观察蔗糖铁注射液联合红细胞生成素治疗伴有缺铁的维持性血液透析。肾性贫血患者疗效及安全性。方法选取尿毒症维持性血液透析患者46例，按随机数字表法分为治疗组（26例）和对照组（20例）。治疗组采用静脉滴注蔗糖铁100mg，每周2次，总量达1000呻后改为100mg，每周1次；对照组采用口服乳酸亚铁0．2g，每日3次。红细胞生成素的使用剂量和方法两组相同，总疗程均为10周。结果经治疗后治疗组患者血红蛋白、红细胞压积、血清铁蛋白水平与对照组比较差异有统计学意义（P〈0．05）。结论蔗糖铁联合红细胞生成素治疗肾性贫血疗效优于口服铁剂联合红细胞生成素治疗。不良反应发生率更低，可作为肾性贫血患者长期补铁的方法之一。Objective To investigate the efficacy and security of iron sucrose combined with erythropoietin on renal anemia. Methods Forty - six cases of uremia patients undergoing maintenance hemodialysis were randomly divided into two groups： the treatment group and the control group. The patients of treatment group （ n = 26） used intravenous iron sucrose 100 mg, twice a week, after a total amount of 1000 mg, then 100 mg, once 1 week. The patients of control group （ n = 20） took orally ferrous lactate 0.2 g , 3 times per day for 10 weeks. Erythropoietin dose was the same in both groups. Results Hemoglobin and hematocrit were significantly higher and serum ferritin significant increased in the treatment group than those in the control group （ P 〈 0.05 ）. Conduslon Clinical observation on the efficiency of intravenous sucrofer combined with erythropoietin in the treatment of renal anemia is effective than conventional oral iron combined with erythropeietin.

关 键 词：蔗糖铁 红细胞生成素 肾性贫血 血液透析 

分 类 号：R692.5[医药卫生—泌尿科学]