支气管哮喘中CD4^+CD_(25)^+调节性T细胞作用的研究进展  

Research Progress on CD4^+CD_(25)^+Regulatory T Cells in Bronchial Asthma

作　　者：冯琳琳[1] 代继宏[1] 符州[1] 

机构地区：[1]重庆医科大学附属儿童医院呼吸中心,重庆400014

出　　处：《实用儿科临床杂志》2009年第20期1610-1612,共3页Journal of Applied Clinical Pediatrics

基　　金：重庆市科委自然科学基金项目资助(CSTC2007BB0268)

摘　　要：支气管哮喘是一种儿童时期最常见的慢性疾病,单纯的Thl/Th2应答失衡并不能完全解释支气管哮喘的发生,伴随着CD4+CD25+调节性T(Treg)细胞的研究进展,人们发现与CD4+CD25+Treg细胞相关的因素如叉头/翼状螺旋转录因子、血红蛋白加氧酶-1、转化生长因子β、细胞毒性T淋巴细胞相关抗原-4与支气管哮喘均有密切的联系。Bronchial asthma is the most common chronic diseases in children. Asthma can not be fully explained by imbalance of Thl/ Th2. With the research progress of CD4^＋ CD25^＋ Treg cell, it has been found that CD4^＋ CD25^＋ Treg cell related factors such as forkhead/ winged helix transcription factor, heine oxygenase - 1, transforming growth factor - β, cytotoxic T lymphocyte - associated antigen - 4 are closely linked to asthmatic mechanisms.

关 键 词：支气管哮喘 CD4^+CD25^+T细胞 叉头/翼状螺旋转录因子 血红蛋白加氧酶-1 转化生长因子Β 细胞毒性T淋巴细胞相关抗原-4 

分 类 号：R725.6[医药卫生—儿科]