人参皂苷Rg_2对大鼠体内血栓形成及血小板聚集的影响  

Effects of Ginsenoside Rg_2 on Thrombogenesis and Platelet Aggregation in Rats

作　　者：田建明[1] 宋丽晶[1] 李浩[1] 叶金梅[1] 李龙云[1] 

机构地区：[1]吉林省中医药科学院中药所安全评价中心,吉林长春130021

出　　处：《上海中医药杂志》2009年第11期79-80,共2页Shanghai Journal of Traditional Chinese Medicine

基　　金：吉林省科技发展计划项目(200250503-3)

摘　　要：目的观察人参皂苷Rg2对动物体内血栓形成时间及血小板聚集率的影响。方法采用体内血栓形成时间测定法,测定大鼠体内血栓的形成时间;采用由ADP诱导的血小板聚集率测定法,测定大鼠血小板聚集率。结果Rg2(尾静脉注射2.5-10mg.kg-1)能明显延长大鼠体内血栓的形成时间;Rg2(尾静脉注射2.5-10mg.kg-1)能明显抑制大鼠由ADP诱导的血小板聚集率。结论人参皂苷Rg2对体内血栓的形成有明显的预防作用,对血小板聚集有明显的抑制作用。Objective To observe the effect of Ginsenoside Rg2 on thrombus formation time and platelet aggregation. Methods The thrombus formation time of rats was measured after injection of Ginsenoside Rg2 and the platelet aggregation fraction was determined after induced by ADP. Results Ginsenoside Rg2 （ iv 2.5-10 mg · kg^-1 ） could extend the time of thrombus formation in rats and suppress platelet aggregation fraction. Conclusion Ginsenoside Rg2 can prevent thrombus formation and inhibit platelet aggregation.

关 键 词：人参皂苷RG2 血栓形成时间 血小板聚集率 药理学 

分 类 号：R285.5[医药卫生—中药学] R965.1[医药卫生—中医学]