糖基化低密度脂蛋白、氧化低密度脂蛋白和2型糖尿病合并下肢血管病变的关系  

GLYCOSYLATED LOW-DENSITY LIPOPROTEIN AND OXIDIZED LOW-DENSITY LIPOPROTEIN IN TYPE 2 DIABETES MELLITUS WITH LOWER EXTREMITY VASCULAR DISEASE

作　　者：赵学慧[1] 杨志宏[1] 杨桂芝[1] 杨桂凤[1] 李芳[1] 王小娟[1] 张鹏宇[1] 郜琳[1] 

机构地区：[1]河北省秦皇岛市第一医院综合2科,秦皇岛066000

出　　处：《现代预防医学》2009年第22期4370-4372,共3页Modern Preventive Medicine

基　　金：河北省秦皇岛市2006年度科学技术研究与发展指导计划项目

摘　　要：[目的]探讨血清糖基化低密度脂蛋白、氧化低密度脂蛋白在T2DM合并下肢血管病变中的作用,同时说明在血管病变防治中抗糖化、抗氧化治疗同样重要。[方法]测定178例糖尿病患者和60例对照组(健康体检)的血清,糖基化低密度脂蛋白和氧化低密度脂蛋白水平,血清GLDL采用氯化硝基四氮唑蓝比色法,血浆OXLDL采用酶联免疫吸附法测定。[结果]①2型糖尿病患者血清糖基化低密度脂蛋白(0.396±0.079)mmol/L,与正常对照组相比增高(0.266±0.072)mmol/L,2型糖尿病血浆氧化低密度脂蛋白(58.266±24.203)μg/dl明显高于对照组(33.349±8.340μg/dl,差异均有统计学意义(P﹤0.01)。②2型糖尿病并发周围血管病组的血清糖基化低密度脂蛋白(0.415±0.073)mmol/L,较无血管病组(0.372±0.084)mmol/L增高,血浆氧化低密度脂蛋白水平2型糖尿病并发周围血管病组(GLDL、)(59.017±24.854)μg/dl,显著高于无周围血管病组(48.356±24.429)μg/dl,差异有统计学意义(P﹤0.01)。③2型糖尿病患者血清糖基化低密度脂蛋白与血浆氧化低密度脂蛋白正相关(r=0.712,P﹤0.01)。[结论]糖基化低密度脂蛋白、氧化低密度脂蛋白和2型糖尿病合并下肢血管病变有关。[Objective] To study the relationship between type 2 diabetes mellitus with lower extremity vascular disease and the serum Glycosylated Low-density lipoprotein（GLDL） or the plasma oxidized low-density lipoprotein（OXLDL）,and clarify the important of prevention and treatment of vascular lesions in the anti-glycosylated,antioxidant treatment.[Methods] The levels of the serum GLDL was measured by a fructosamine method and that of the plasma OXLDL was estimated by ELISA among 178 cases with type 2 diabetes mellitus and 60 controls.[Results] ① The levels of both the serum GLDL and the plasma OXLDL in type 2 diabetes mellitus were significantly higher than those in controls（P﹤0.01）.② The levels of both the serum GLDL and the plasma OXLDL in type 2 diabetes mellitus with lower extremity vascular disease significantly increased in comparison with type 2 diabetes mellitus without lower extremity vascular disease（P﹤0.01）.③ Positive correlation was found between the levels of the serum GLDL and that of the plasma OXLDL（=0.712,P﹤0.01）.[Conclusion] The measurements of GLDL and OXLDL are very important clinical value in treatment of type 2 diabetes mellitus with lower extremity vascular disease.

关 键 词：2型糖尿病 下肢血管病变 糖基化低密度脂蛋白 氧化低密度脂蛋白 

分 类 号：R587.1[医药卫生—内分泌]