黏附分子CD146在IgA肾病肾小管的表达及临床意义  

Expression of Adhension Molecule CD146 in Renal Tubular Epithelial Cells and Its Clinical Significance in IgA Nephropathy

作　　者：冀玲[1] 吴桂明[1] 杨立川[1] 李凌[1] 徐缓[2] 

机构地区：[1]四川大学华西医院肾内科,成都610041 [2]四川大学华西医院病理科,成都610041

出　　处：《四川大学学报（医学版）》2009年第6期1049-1052,共4页Journal of Sichuan University(Medical Sciences)

摘　　要：目的探讨黏附分子CD146在IgA肾病肾小管上皮细胞的表达及其与临床指标之间的关系。方法应用免疫组化法检测44例IgA肾病肾穿刺活检组织中CD146的表达情况,收集性别、年龄、血压、24 h尿蛋白、血肌酐等临床指标,对肾间质纤维化进行分度,计算肾小球硬化指数,分析各项指标与CD146表达的关系。结果CD146阳性着色主要见于肾小管上皮细胞,在小管周围微血管内皮细胞、平滑肌细胞亦可见。CD146在肾小管上皮细胞的表达男性患者强于女性患者(Z=-2.096,P=0.036),高血压患者、血肌酐增高患者及血甘油三酯增高患者CD146表达水平分别高于血压正常者、血肌酐正常者及血甘油三酯正常者(Z=-2.738、-2.166、-2.313,P=0.006、0.030、0.021)。相关性分析发现CD146在肾小管上皮细胞的表达与24 h尿蛋白(r=0.381,P=0.011)、肾小球硬化指数(r=0.410,P=0.006)、间质纤维化程度(r=0.311,P=0.040)之间均有正相关性。结论CD146分子参与了肾间质纤维化过程。Objective To detect the expression of adhension molecule CD146 in renal tubular epithelial cells and its clinical significance in IgA nephropathy.Methods The expression level of CD146 was measured by immunochemistry method in serial sections of 44 specimens from the patients with biopsy-proven IgA nephropathy.The relationship between CD146 expression and clinicopathological changes was analyzed.Results CD146 was mainly expressed in renal tubular epithelial cells,also slightly in the endothelial cells of peritubular capillary and smooth muscle cells.The expression of CD146 had no relationship with Lee＇s grade of IgA nephropathy,but positively correlated with 24-hour urine protein（r =0.381,P =0.011）,hypertention,serun creatinine,triglyceride（Z =-2.738,-2.166,-2.313,P =0.006,0.030,0.021）,index of glomerular sclerosis（r =0.410,P =0.006）,degree of interstitial fibrosis（r =0.311,P =0.040）.Conclusion CD146 might play an important role in the progression of renal interstitial fibrosis.

关 键 词：黏附分子 CD146 IGA肾病 肾间质纤维化 

分 类 号：R692.3[医药卫生—泌尿科学]