多沙唑嗪控释片和坦索罗辛治疗良性前列腺增生疗效及安全性的Meta分析  

Comparison of Controlled Release Doxazosin and Tamsulosin in Treating Benign Prostatic Hyperplasia:a Systematic Review

作　　者：刘冬[1] 吕永安[1] 邵晋凯[1] 

机构地区：[1]山西省人民医院泌尿外科,太原030012

出　　处：《医学研究杂志》2009年第9期63-67,共5页Journal of Medical Research

摘　　要：目的系统评价多沙唑嗪控释片(controlledrelease doxazosin)和坦索罗辛(tamsulosin)对照治疗BPH的疗效与安全性。方法搜集国内运用多沙唑嗪和坦索罗辛两种药物对比治疗BPH的随机对照试验(randomized controlled trials,RCTs)中英文文献,并追查已纳入文献的参考文献。由至少两位系统评价员做独立文献筛查、质量评价和资料提取,并交叉核对。使用统计软件RevMan5.0完成Meta分析。结果经筛选,最后纳入6篇文献,均为RCT,包括受试患者686例,进行Meta分析,其基线情况具有可比性。通过比较用药前后2个判效指标,即国际前列腺症状评分(IPSS)、最大尿流率(Qmax),发现多沙唑嗪控释片和坦索罗辛在改善BPH上述2个判效指标方面无差别(P>0.05);两组用药后不良反应比较示多沙唑嗪控释片导致恶心少于坦索罗辛(P<0.05),其他无明显差别(P>0.05)。结论多沙唑嗪控释片和坦索罗辛均可改善BPH症状,且在改善客观和主观指标方面无明显差别。因纳入文献和样本量有限,建议进行大样本、长期随访的高质量临床试验,提供更佳循证证据。Objective To systematically review and evaluate the effectiveness and safety of two α - antagonists , controlled release doxazosin and tamsulosin for treating benign prostatic hyperplasia （BPH） comparatively. Methods Chinese and English studies were sought and included in the review if they were RCTs （ randomized controlled trials） involved men with BPH, compared controlled release doxazosin with tamsulosin and revealed the effectiveness and safety comparatively in the outcomes. Two reviewers independently screened the studies for eligibility, evaluated the quality and extracted the data from the eligible studies, with confirmation by cross - checking. Data were processed by RevMan 5.0. Results Six studies involving 686 men met the inclusion criteria, which were included in the Meta a- nalysis. The baseline of patients＇ characteristics were comparable in all the studies. By comparing the six common criteria , we found that no different efficacy between the two drugs was displayed at IPSS and Qmax （P 〉 0.05）. Nausea of controlled release doxazosin was less than tamsulosin＇ s （P 〈 0. 05）. Conclusion Our results show that either controlled release doxazosin or tamsulosin can be used to treat BPH patients on the basis of objective and subjective assessment of voiding symptoms. Because of few studies and small samples, more high quality trials with large samples and longer following - up are proposed.

关 键 词：良性前列腺增生 多沙唑嗪 坦索罗辛 META分析 

分 类 号：R544.1[医药卫生—心血管疾病] R195.1[医药卫生—内科学]