低分子肝素降低过敏性紫癜复发及紫癜性肾炎风险的疗效评价  

Efficacy Assessment of Low Molecular Heparin on Recurrence of Anaphylactic Purpura and Occurrence of Purpuric Nephritis

作　　者：杨勇[1] 金蕊[1] 

机构地区：[1]扬州市第一人民医院,江苏扬州225017

出　　处：《临床误诊误治》2009年第11期5-6,共2页Clinical Misdiagnosis & Mistherapy

摘　　要：目的：探讨低分子肝素对降低过敏性紫癜反复发作及紫癜性肾炎风险的疗效。方法：收集2002～2008年我院收治的211例小儿过敏性紫癜，按首次发作是否使用了低分子肝素治疗分为治疗组148例和对照组63例。治疗组在常规治疗基础上加用低分子肝素80μg·kg^-1·d^-1加入5％葡萄糖中静脉滴注，10～14天为一疗程。对两组过敏性紫癜复发率及紫癜性肾炎的发生率进行回顾性分析。结果：治疗组紫癜复发35例，复发率为23．6％；发生紫癜性肾炎20例，发生率为13．5％。对照组紫癜复发34例，复发率为54．0％；发生紫癜性肾炎25例，发生率为39．7％。结论：低分子肝素治疗过敏性紫癜方法简单，价格适中，临床早期使用可降低紫癜的复发和紫癜性肾炎的发生风险。Objective：To explore the therapeutic effects of low molecular Heparin on the children with anaphylactic purpura. Methods ：The clinical data of 211 patients with anaphylactic purpura admitted to our hospital during 2002-2008 were analyzed retrospectively. The patients were randomly divided into low molecular heparin treated group（ n = 148） and control group（ n = 63 ）.The treated group was given 80μg·kg^-1·d^-1 of low molecular Heparin in 5% glucose liquid iv. gtt. Results： In the treatment group, 35 patients had a relapse, with a recurrence rate of 23.6% ; 20 patients followed by nephritis, with an occurrence rate of 13.5%. In the control group, 34 patients had a relapse, with a recurrence rate of 54.0% ; 25 patients followed by nephritis, with an occurrence rate of 39.7%. Conclusion ： Low molecular heparin can decrease recurrent of anaphylactic purpura and reduce risk of purpuric nephritis.

关 键 词：紫癜 过敏性 肾炎 肝素 低分子量 治疗结果 

分 类 号：R554.6[医药卫生—血液循环系统疾病]