Zn/I_2促进的S—S键断裂用于合成α-硫代酯和α-硫代腈  

Synthesis of α-thio esters and nitriles via cleavage of S—S bonds promoted by Zn/I_2 in DMF

作　　者：张耀红[1] 周列锦[1] 王小霞[1] 刘俊华[1] 

机构地区：[1]浙江师范大学化学与生命科学学院化学系,浙江金华321004

出　　处：《浙江师范大学学报（自然科学版）》2009年第4期437-441,共5页Journal of Zhejiang Normal University:Natural Sciences

摘　　要：二硫醚在二甲基甲酰胺（DMF）中被Zn/I2还原,发生S—S键的断裂,生成硫负离子,随后与α-溴乙酸乙酯或α-溴乙腈反应,分别生成α-硫代酯和α-硫代腈,产率为79%-91%.Thio anions,which were produced by reductive cleavage of disulfides by Zn/I2 in DMF,underwent nucleophilic substitution with α-bromo ethyl acetate and α-bromo acetonitrie smoothly,α-thio esters and α-thio nitriles were obtained with good yields rate of 79%~91%.

关 键 词：Zn/I2 二硫醚 α-硫代酯 α-硫代腈 亲核取代 

分 类 号：O623.82[理学—有机化学]