碳酸钙泡腾颗粒的人体生物利用度研究  

The bioavailability of calcium carbonate effervescent granules in healthy volunteers

作　　者：周天杰[1,2,3] 洪诤[1,2,3] 程小宁[1,2,3] 赵劲松 何文淑 熊宏智 

机构地区：[1]华西医科大学附属职业病防治院 [2]华西医大药学院 [3]四川健益医药工业研究所

出　　处：《中国医院药学杂志》1998年第12期533-535,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的：评价碳酸钙泡腾颗粒的人体生物利用度。方法：以原子吸收光谱法测定１０名健康志愿者口服碳酸钙泡腾颗粒与进口碳酸钙片后的尿钙浓度，以尿钙总排泄量与尿钙增量为指标评价两种制剂吸收差异。结果：口服１．２ｇ碳酸钙泡腾颗粒与碳酸钙片后４ｈ尿钙总排泄量分别为０．１４３ｍｇ·（ｍｇＣｒ）－１与０．１０９ｍｇ·（ｍｇＣｒ）－１；尿钙增量分别为０．０５１ｍｇ·（ｍｇＣｒ）－１与０．０３１ｍｇ·（ｍｇＣｒ）－１，前者均显著高于后者（Ｐ＜０．０５和Ｐ＜０．０１）。结论：碳酸钙泡腾颗粒的口服生物利用度高于碳酸钙片。Objective:To investigate the bioavailability of calcium carbonate effervescent granules in healthy volunteers.Methods:The urinary calcium were determined by atomic absorption spectrophotometry after a single oral dose of calcium carbonate effervescent granules and calcium carbonate tablet was given to 10 healthy volunteers.Results:The urinary calcium following calcium carbonate effervescent granules was significantly higher whether expressed as the total amount or as the increment above basal (fasting) excretion.Conclusion:The bioavailability of calcium carbonate effervescent granules was higher than calcium carbonate tablet.

关 键 词：碳酸钙泡腾颗粒 生物利用度 补钙剂 

分 类 号：R977.5[医药卫生—药品] R969[医药卫生—药学]