非流利失语型额颞叶痴呆患者神经心理学特征及皮质代谢功能变化  

Cortex function and neuropsychological changing of non fluent aphasia type-frontal temple dementia GAO

作　　者：高晶[1] 李芳[2] 朱朝晖[2] 冯逢[3] 有慧 彭斌[1] 郭佳翔[1] 孟琼[1] 郭玉璞[1] 

机构地区：[1]中国医学科学院北京协和医院神经内科,100730 [2]中国医学科学院北京协和医院核医学科 ,100730 [3]中国医学科学院北京协和医院核磁共振室 ,100730

出　　处：《中华神经科杂志》2009年第11期733-736,共4页Chinese Journal of Neurology

摘　　要：目的正规的认知功能评价结合脱氧葡萄糖正电子发射断层摄影术（FDG—PET）检查和影像学改变，分析非流利失语型额颞叶痴呆（FTD）患者的神经心理学特征。方法选择临床、影像、皮质葡萄糖代谢功能以及神经心理学评价均符合非流利失语型FTD患者，动态评价其神经语言学以及多种认知功能。按其特殊的神经心理学特点结合FDG-PET分析神经心理学改变的皮质基础。结果5例患者的核心症状均为隐袭起病、慢性进行性的非流利型失语，伴随的突出改变为视空间、字词级阅读保留好，记忆相对好，以非语言记忆保留更突出，生活适应能力损害相对晚。患者均有相应的皮质糖代谢改变基础。结论非流利失语型FTD患者的视空间能力、字词级阅读能力以及生活适应能力损害晚，与相应的皮质代谢功能相关，可以帮助照料者有效指导、调整患者的适应能力训练。Objective To analyse the neuropsychologieal changing of nonfluent aphasia frontotemporal dementia （nf-FTD） with the FDG-PET, MRI and tMRI. Methods The language and other cognitive function were dynamically estimated by standard neuropsychological assessment which modified by Chinese. Compared with FDG-PET and fMRI, the relationship between the neuropsychological changing and the cortex function was studied. Results All the 5 patients met the criteria of nf-FTD by Association for Frontotemporal Dementias, with core syndrome and other supptted syndrome. And still they had the good word reading, calculation by pen, and the un-speechmemory. And they also had the related well living ability. They all had the related cortext metabolism support. Conclusions nf-FTD patients preserve the word reading, visuapacial ability and calculation by pen. These can help us to give the effective advise about the patients training and caring and to give them the chance to show their real social skill.

关 键 词：痴呆 失语 经皮质运动性 神经心理学 正电子发射断层显像术 

分 类 号：R686[医药卫生—骨科学]