头孢西丁治疗与预防外科感染的疗效  

Effect of treatment and prophylaxis of cefoxitin in surgery

作　　者：时德[1] 白麟祥[1] 刘象和 

机构地区：[1]重庆医科大学临床学院外科

出　　处：《重庆医科大学学报》1998年第4期408-410,共3页Journal of Chongqing Medical University

摘　　要：采用头孢西丁治疗外科感染84例,总有效率89.3%。预防手术切口感染40例,在Ⅰ类切口中无显著差异,在Ⅱ类切口中,手术前给予头孢西丁预防手术切口感染较之术后给予庆大或卡那霉素加氨苄青霉素加甲硝唑或替硝唑更为有效。Eighty-four patients with surgical infections were treated with cefoxitin The total effective rate was 89.3%. To determine the best antibiotic regimen to employ in patients undergoing surgery,a randomized prospective study was designed comparing cefoxitin alone with a triple-drug of gentamycin or kanancycin,ampicillin and metronidazole or tinidazole.Eighty patients were divided into two groups.The prophylaxis was started preoperatively or postoperatively.In both groups wound infections was found to be less than 9.5 percent and no difference could be demonstrated in type Ⅰ operative incision.However cefoxitin was significantly superior to triple-drug in type Ⅱ operotive incision(P<0.05). Cefoxitin offers a single drug prophylaxis that adequately reduces postoperative infectious complications in patients undergoing surgery.

关 键 词：头孢西丁 预防 外科感染 药物疗法 

分 类 号：R630.5[医药卫生—外科学] R978.11[医药卫生—临床医学]