体外反搏对失血性休克犬心肌能量及自由基代谢的影响  

Effect of ECP on energy and free radical metabolism in hemorrhagic shock canine

作　　者：谭红梅[1] 吴伟康[1] 罗汉川[1] 周少春[2] 郑振声[2] 詹澄扬[2] 

机构地区：[1]中山医科大学病理生理教研室 [2]中山医科大学卫生部辅助循环重点试验室

出　　处：《中国病理生理杂志》1998年第6期631-633,共3页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金

摘　　要：目的：体外反搏在治疗许多缺血性疾病中有良好的效果，本文在重症失血性休克模型上探讨其保护机制。方法：采用一侧颈总动脉插管放血制造重症失血性休克模型，全程监测血压，实验结束时取左室心肌进行各项检查。结果：①反搏组反搏后血压显著高于反搏前，且实验结束时反搏组的血压也显著高于失血组。②失血组心肌内ＡＴＰ水平显著低于对照组及反搏组，而乳酸含量显著高于对照组及反搏组。③失血组心肌ＭＤＡ含量显著高于对照组及反搏组，而ＳＯＤ的活性则显著低于反搏组及对照组。Abstract AIM:To explore the protective mechanisms of ECP (external counterpulsation) on ischemia diseases such as coronary heart disease, ischemia apoplexy and hemorrhagic shock (HS). METHODS:The model of serious hemorrhagic shock was used. After the whole experiment , hearts were excised to detect parameters of energy and free radical metabolism. RESULTS:Blood pressure of ECP and C groups at the end of experiment was significantly higher than that of HS group. ATP level in ventricular tissue of HS group was significantly lower than that of control and ECP groups ( P <0 05), and lactic acid concentration in ventricular tissue of HS group was significantly higher than that of control and ECP groups ( P <0 05), SOD activity of HS group was significantly lower than that of control and ECP groups ( P <0 05), and MDA concentration of HS group was significantly higher than that of control and ECP groups ( P <0 05).CONCLUSION: ECP protected the canine heart of HS and its mechanism may be related to improvement of metabolism of energy and free radical. MeSH Counterpulsation; Energy metabolism; Free radicals; Myocardium

关 键 词：能量代谢 游离基类 休克 失血性休克 体外反搏 

分 类 号：R605.971[医药卫生—急诊医学]