吸入一氧化氮对犬烟雾吸入性损伤心肌酶谱的影响  

Effect of inhaled nitric oxide on myocardial enzyme spectrum after smoke inhalation injury in dogs

作　　者：齐顺贞[1] 杨建民[1] 林洪武 杨宗城[2] 黎鳌[2] 

机构地区：[1]白求恩国际和平医院烧伤整形科 [2]第三军医大学烧伤研究所

出　　处：《中国病理生理杂志》1998年第6期656-659,共4页Chinese Journal of Pathophysiology

基　　金：全军"八五"攻关课题

摘　　要：目的：本研究旨在评价吸入一氧化氮（ＮＯ）在犬烟雾吸入性损伤时对心肌酶谱的影响。方法：烟雾吸入后，用１７只犬随机分为２组，对照组（ｎ＝８）单纯吸氧（ＦｉＯ２，０４５），治疗组（ｎ＝９）吸氧（ＦｉＯ２，０４５）＋０００４５％（４５ｐｐｍ）ＮＯ，连续监测１２ｈ动脉血心肌酶谱变化。结果：治疗组乳酸脱氢酶（ＬＤＨ）、α－羟丁酸脱氢酶（α－ＨＢＤ）、肌酸激酶（ＣＫ）和天冬氨酸氨基转移酶（ＡＳＴ）均不同程度低于对照组（Ｐ＜００５，＜００１）。Abstract AIM:To evaluates the effect of inhaled nitric oxide (NO) on myocardial enzyme spectrum in smoke inhalation injury. METHODS:After smoke inhalation injury, 17 dogs were divided radomly into 2 groups, control group ( n =8) given inhaled oxygen (FiO 2,0 45) and treated group ( n =9) given inhaled oxygen (FiO 2,0 45) mix with 0 0045% (45ppm) NO. Changes of myocardial enzyme spectrum in arterial blood were observed continuously for 12 hours. The data were analyzed using ANOVA for multiple mean comparisons. [WT5HZ] RESULTS:Lactic dehydrogenase (LDH),α-Hydroxybutyrate dehydrogenase (α-HBD) creatine kinase (CK) and aspartate aminotransferas (AST) of the treated group were lower than the control group ( P <0 05, P <0 01).CONCLUSION:Inhaled NO may decrease myocardial injury in smoke inhalation injury in dogs. MeSH Nitric oxid; Burn; Wounds and injuries; Myocardium; Enzymes

关 键 词：一氧化氮 烟雾 吸入性损伤 心肌酶谱 犬 

分 类 号：R644.02[医药卫生—外科学]