新型氯苯基卟啉-5-氟尿嘧啶的合成  

Synthesis of New Chlorophenyl Porphyrin-5-fluorouracil

作　　者：马红[1] 韩士田[1] 刘彦钦[1] 

机构地区：[1]河北师范大学化学与材料科学学院,河北石家庄050016

出　　处：《合成化学》2009年第6期699-701,共3页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(20601007);河北省自然科学基金资助项目(203147);河北省教育厅科学研究资助项目(2001120)

摘　　要：以3,4-二氯苯甲醛、对羟基苯甲醛,吡咯和1,5-二溴戊烷(或1,6-二溴己烷)为原料,经两步反应合成了溴烷氧基氯苯基卟啉(2a或2b);2与5-氟尿嘧啶反应,合成了两种新型的氯代苯基卟啉-5-氟尿嘧啶[1a(产率28.26%)和1b(产率29.34%)],其结构经UV-Vis,1H NMR,IR和MS表征。Bromine-alkoxy-chlorophenyl porphyrin（2a or 2b） were synthesized by a two-step reaction from 3,4-dichlorobenzaldehyde, p-hydroxybenzaldehyde, pyrrole and 1,5-dibromopentane（ or 1,6-di- bromohexane）. Two new chlorophenyl porphyrin-5-fluorouracils were synthesized by the reaction of 2 with 5-fluorouracil. The yields reached 28.26% and 29.34%, respectively. Their structures were characterized by UV-Vis, 1H NMR, IR and MS.

关 键 词：5-氟尿嘧啶 卟啉 合成 

分 类 号：O626[理学—有机化学]