盐酸坦洛新胃漂浮缓释小丸的制备与体外释放  

Preparation and in vitro release of tamsulosin hydrochloride in floating stagnation sustained release pellets

作　　者：刘艳红[1] 徐文奎 马德宝 姜同英[1] 王思玲[1] 孙长山[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]沈阳铁西区华康医院,辽宁沈阳110026 [3]青岛黄海制药有限责任公司,山东青岛266101

出　　处：《沈阳药科大学学报》2009年第11期852-856,共5页Journal of Shenyang Pharmaceutical University

摘　　要：目的研制盐酸坦洛新胃漂浮缓释小丸并考察其体外释放特性。方法采用液中干燥法制备胃漂浮小丸,以收率、圆整度、平均粒径、释放度和漂浮性为指标,考察处方工艺因素对小丸性能的影响。结果圆整度较好,小丸收率质量分数在75%以上,随搅拌速度增加粒径减小,体外缓释8 h,漂浮效果较好。结论盐酸坦洛新胃漂浮缓释小丸具有较好的漂浮及缓释性能,是一种较理想的口服缓释制剂。Objective To prepare tamsulosin hydrochloride in floating sustained release pellets and investigate the drug release mechanism in vitro. Methods Pellets were prepared by solvent diffusion and evaporation method, the yield, angle of repose, mean diameter, drug release and buoyancy were used to evaluate the influence of different formulations and preparation factors. Results The pellets were of a round form, the yields were more than 75 % （w）, the mean sizes were decreased with increasing the stirring rate, and exhibited prolonged drug release and remained buoyancy more than 8 h in artificial gastric juice. Conclusions The prepared pellets show excellent floatability and drug release. These results suggest that they are ideal oral extended release dosage system.

关 键 词：盐酸坦洛新 液中干燥法 胃漂浮小丸 

分 类 号：R94[医药卫生—药剂学]