高同型半胱氨酸血症与多发性硬化关系的荟萃分析  

Meta-analysis on relationship between hyperhomocysteinemia and multiple sclerosis

作　　者：朱颖[1] 刘鹤南[2] 张朝东[1] 梁会营[3] 

机构地区：[1]中国医科大学附属第一医院神经内科,110001 [2]中国医科大学附属盛京医院眼科 [3]中国医科大学公共卫生学院流行病学教研室

出　　处：《中华医学杂志》2009年第43期3055-3057,共3页National Medical Journal of China

摘　　要：目的综合评价高同型半胱氨酸血症与多发性硬化的关系。方法全面检索Cochrane、Medline、EMbase、Springerlink、Highwire、CBM、CNKI、维普和万方等中英文数据库，获得有关同型半胱氨酸与多发性硬化关系的研究结果，对其进行方法学质量评价、筛选和异质性检验，要求所纳入文献的设计均为病例对照研究。采用Stata 8．0软件对提取的数据进行分析。结果有9篇文献进入Meta分析，共获得1146例样本，其中病例组676例，对照组470例。Meta分析结果显示，MS组血浆同型半胱氨酸水平显著高于对照组（标准化均差为1．25，95％可信区间为0．48～2．01）。敏感性分析显示两组在血浆同型半胱氨酸水平上的差异结果可靠。结论高同型半胱氨酸血症与MS具有相关性，它可能在MS的病理过程中起一定作用。Objective To determine the relationship between hyperhomocysteinemia and multiple sclerosis （MS）. Methods Coehrane, Medline, EMbase, Springerlink, Highwire, CBM, CNKI and some other databases were searched for literatures. Articles were identified using the Medical Subject Heading term ＂hyperhomoeysteinemia, homocysteine, multiple sclerosis＂. The methodological quality of internalized literatures were valuated, screened and heterogeneity tested. Case control studies involving unrelated subjects and valid data were extracted and analyzed in Stata 8.0. Results Nine studies were included in this review. The involved 1146 subjects were made of 676 patients and 470 controls. A meta-analysis showed that the level of homoeysteine in MS was higher than that in controls （ standardized mean difference 1.25, 95% CI：0. 48 - 2.01 ） . The analytical result of sensitivity proved that the result of meta-analysis was coherent. Conclusion Hyperhomoeysteinemia is associated with MS, and it may contribute to the pathological course of MS.

关 键 词：高同型半胱氨酸血症 多发性硬化 META分析 

分 类 号：R686[医药卫生—骨科学]