碘化壳聚糖季铵盐的急性毒性及降脂作用实验研究  

Acute Toxicity and Lipid-lowering Effect of N-trimethyl Chitosan Iodide

作　　者：郭东华[1] 黄赫坤[1] 柏亚林[1] 温晓娜[2] 孟舒献[3] 

机构地区：[1]天津市儿童医院药剂科,天津市300074 [2]天津市第三中心医院药剂科,天津市300170 [3]天津大学化工学院,天津市300072

出　　处：《中国药房》2009年第34期2655-2657,共3页China Pharmacy

基　　金：天津市自然科学基金资助项目(043610611)

摘　　要：目的:研究碘化壳聚糖季铵盐(TMCI)对小鼠的急性毒性作用和对大鼠的降脂作用。方法:分别给予小鼠小、大剂量(2.25、4.50g·kg-1·d-1)的TMCI7d,记录小鼠体质量;将大鼠随机分为空白组、高脂模型组、考来烯胺(CLST)组和TMCI组,后3组建立高脂模型3周,再分别给予相应药物,给药前及给药后2、4周取血测定各组大鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平及体质量。结果:小、大剂量的TMCI对小鼠生长无明显影响;与给药前比较,大鼠TMCI组HDL-C水平升高,TG、TC、LDL-C降低(P<0.05或P<0.01),但作用不如CLST明显。结论:TMCI对小鼠具有良好的生物安全性,经口服给药后对高血脂模型大鼠具有一定的改善作用。OBJECTIVE： To explore the acute toxicity on mice and lipid lowering effect on rats of N - trimethyl chitosan iodide （TMCI）. METHODS： The mice were assigned to receive TMCI at low and high doses （2.25, 4.50 g·kg-1·d-1） for 7 days, with body weight recorded. Then the rats were randomly divided into 4 groups： blank normal group, hyperlipemia model group, cholestyramine （CLST） group, and TMCI group. Hyperlipemia model was established for the latter 3 groups before receiving corresponding drugs. Serum total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-- C）, low density lipoprotein cholesterol （LDL- C）, and body weight were measured before medication and at 2 and 4 weeks after medication, respectively. RESULTS： Treatment with TMCI at low and high doses showed insignificant impact on mice growth （body weight） . Compared with before medication, TMCI treatment group showed increase in HDL-C level but de- crease in TG, TC and LDL- C levels （P〈 0.05 or P 〈 0.01）, however, these effects were lower than CLST. CONCLUSION： TMCI has good biosecurity in mice and it has certain beneficial effect on hyperlipemia model rats after oral administration.

关 键 词：碘化壳聚糖季铵盐 考来烯胺 高脂血症 大鼠 小鼠 急性毒性 降脂作用 

分 类 号：R965[医药卫生—药理学] R972.6[医药卫生—药学]