复方苯酚溶液中抗氧剂的筛选  

Optimization of the Antioxidants for Compound Phenol Solution

作　　者：苏艳清[1] 张荣[1] 黄艺蓉[1] 郑绍忠[1] 肖海英[1] 

机构地区：[1]解放军第175医院/厦门大学附属东南医院药剂科,漳州市363000

出　　处：《中国药房》2009年第34期2662-2664,共3页China Pharmacy

摘　　要：目的:筛选复方苯酚溶液的抗氧剂,以提高其稳定性。方法:采用经典恒温法和留样观察法对7份含有不同抗氧剂(0、0.1%、0.15%、0.2%浓度的硫代硫酸钠和亚硫酸钠)的复方苯酚溶液中苯酚含量、溶液pH值及外观颜色进行考察,并预测溶液的有效期,优选出有效期最长的处方;采用稀释法测定优选处方及未加抗氧剂的对照处方的最低杀菌浓度(MBC),考察抗氧剂的加入对杀菌作用的影响。结果:以0.1%硫代硫酸钠为抗氧剂的处方中苯酚含量、pH值及外观颜色的变化均较其它6份处方小,有效期为8.5个月,MBC值与对照处方相同。结论:复方苯酚溶液中加入0.1%硫代硫酸钠作为抗氧剂可提高溶液稳定性且不影响杀菌效果。OBJECTIVE： To optimize the antioxidant for compound phenol solution to improve its stability. METHODS： The change in phenol content, pH and color of 7 compound phenol solution samples containing different antixidants （Na2S2O3 and Na2SO3 at concentrations of 0, 0.1%, 0.15%, and 0.2%） was observed by classical isothermal method, and the expiry term of the solution was predicated to obtain the formulation that with the longest expiry term. A dilution method was applied to optimize the minimal bactericidal concentrations （MBC） of the optimized formulation and the control （in which no antioxi- dant was added）, and the effect of the addition of antixidant on the bactericidal action was investigated. RESULTS： The so- lution which was added with 0.1%Na2SK）a as antioxidant witnessed the least change in color, pH and the phenol content compared with the other 6 samples, with an expiry term of 8.5 months. MBC of the optimized formulation was the same as that of the control formulation. CONCLUSION： Addition of 0.1% Na2SK）a as antioxidants contributes to the enhanced sta- bility of compound phenol solution yet without affecting its bactericidal action.

关 键 词：复方苯酚溶液 硫代硫酸钠 抗氧剂 经典恒温法 最低杀菌浓度 

分 类 号：R965[医药卫生—药理学] R979.7[医药卫生—药学]