牛黄解毒片的遗传毒性研究  

Genotoxicity of Bezoar Antidotal Tablets

作　　者：董菊[1] 唐萌[2] 王姝[2] 

机构地区：[1]南京中医药大学基础医学院预防医学教研室,江苏南京210046 [2]东南大学公共卫生学院,江苏南京210009

出　　处：《癌变．畸变．突变》2009年第6期477-478,485,共3页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：南京中医药大学青年科技基金资助项目(07XZRO2)

摘　　要：背景与目的:评价牛黄解毒片是否具有遗传毒性作用。材料与方法:采用Ames试验、小鼠骨髓细胞微核试验和小鼠精子畸形试验对牛黄解毒片进行遗传毒性检测。结果:Ames试验各剂量组回变菌落数均未超过溶剂对照组的2倍,3个剂量组的微核率和精子畸形率与溶剂对照组比较,差异均无统计学意义(P>0.05)。结论:在本试验条件下,牛黄解毒片未见遗传毒性作用。BACKGROUND AND AIM： To evaluate the genotoxicity of bezoar antidotal tablets. MATERIALS AND METHODS： The Ames test, the mouse mieronucleus test and the mouse sperm abnormality test were used to evaluate the genotoxicities of bezoar antidotal tablet. RESULTS： In the Ames test, the number of revertants in all dose groups was less than twice that of solvent control group. In the mouse micronucleus test and sperm abnormality test, no significant differences were observed in the three dose groups compared with that of control group. CONCLUSION： Under this experimental condition, no genotoxic effects had been found in bezoar antidotal tablets.

关 键 词：雄黄 牛黄解毒片 遗传毒性 

分 类 号：R994.4[医药卫生—毒理学]