决明子降脂保肝胶囊的CO2超临界萃取工艺研究  

Study of CO2 Supercritical Technology on Extraction from Cassia seed Jiangzhi Baogan Capsule

作　　者：郝红梅[1] 刘必旺[1] 赵换[1] 吉海杰[1] 周然[1] 尤舒彻[1] 

机构地区：[1]山西中医学院

出　　处：《中国中医药现代远程教育》2009年第11期153-154,共2页Chinese Medicine Modern Distance Education of China

基　　金：山西省知识产权局专利推广项目[编号:081006];山西省卫生厅科技发展计划项目[编号:200223];山西省卫生厅科技攻关计划项目[编号:200724];山西省教育厅立项项目[编号:200811038]

摘　　要：目的研究CO2超临界萃取决明子降脂保肝胶囊中有效成分之一的蒽醌类化学物质的最佳工艺条件,考察各工艺参数对蒽醌类化学物质的影响。方法以决明子降脂保肝胶囊中蒽醌类化学物质的含量为主要指标,采用L（3）4正交设计优选CO2超临界萃取的蒽醌类化学物质最佳工艺条件。结果CO2超临界萃取温度、萃取压力及萃取次数均对蒽醌类化学物质有较大影响,以萃取温度为60℃,萃取压力为60mPa,萃取2次,每次1.5h时,蒽醌类化学物质的萃取最佳。结论CO2超临界萃取可用于决明子降脂保肝胶囊的生产,且工艺条件简单、稳定、可行。Objective To study the optimum CO2 supercritical technological conditions of extraction from Cassia seed Jiangzhi Baog an capsule and investigate the impacts of every technological parameter.Methods extraction content in extract were taken as the main inde xes. L （3） 4orthogonal design was adopted to optimize the technological conditions of supercritical CO2 extraction. Results CO2 supercr itical extraction temperature, the extraction pressure and extraction times had greatly influenced the extraction.At the extraction temperature of 60℃, the extraction pressure of 40 MPa and 2 times of extraction.once every 1.Sho Conclusion CO2 supercritical extraction can be u sed for the extraction of active ingredient, The technological conditions are simple, stable and feasible.

关 键 词：决明子降脂保肝胶囊 CO2超临界萃取 正交试验 

分 类 号：R286.0[医药卫生—中药学]