氨酚羟考酮镇痛效果的临床观察  

Analgesic efficacy of oxycodone-acetaminophen tablets in the treatment of pain

作　　者：王锁良[1] 申小东[1] 王辉[1] 候海涛[1] 

机构地区：[1]西安交通大学医学院第一附属医院,西安710061

出　　处：《中国新药杂志》2009年第22期2135-2137,共3页Chinese Journal of New Drugs

摘　　要：目的：观察氨酚羟考酮对临床常见疼痛性疾病及中晚癌痛的镇痛疗效和不良反应。方法：选取门诊非癌性疼痛病例50例,中晚期癌痛患者30例,口服氨酚羟考酮片,每次1-2片,bid或tid,非癌性疼痛组观察5 d为1个疗程,中晚期癌痛组7 d为1个疗程,观察疼痛的缓解率及不良反应。结果：两组患者均取得良好的镇痛效果,疗程结束时的总有效率达100%,在非癌性疼痛患者中疼痛的完全缓解率为87.3%,癌性疼痛患者中完全缓解率为70%。不良反应包括头晕、嗜睡、恶心、呕吐、便秘,未见明显的呼吸抑制及精神依赖性发生。结论：氨酚羟考酮用于治疗临床非癌性疼痛和中晚期癌痛,疗效确切,不良反应小。Objective：To observe the analgesic efficacy and side effects of oxycodone-acetaminophen tablets for the painful diseases and the cancer pain at middle and advanced stages.Methods：Out-patients with non-cancer pain（n=50,painful disease） and patients with cancer pain（n=30） were enrolled,and treated with oxycodone-acetaminophen 1～2 tablets,bid or tid.The analgesic effects and side effects were respectively observed 5 days after treatment in painful disease group,and 7 days after treatment cancer pain group. Results ： The analgesic efficacies were satisfactory in both groups; the total pain relief rate was 100%. The complete relief rate was 87.3% in painful disease group and 70% in cancer pain group. The side effects included dizziness, lethargy, nausea, vomiting, and constipation. No obvious respiratory depression and psychological dependence were observed. Conclusion： oxycodone-acetaminophen has definite analgesic effect and slight adverse reactions in the treatment of painful diseases and cancer pain.

关 键 词：氨酚羟考酮 镇痛效果 非癌性疼痛 癌性疼痛 

分 类 号：R971[医药卫生—药品]