药物醋柳酯合成的改进  

Technological improvement of guaiaspir synthesis

作　　者：陈小全[1] 仇玉芹[2] 周秀艳[3] 翟虎[1] 邵辉莹[1] 毕玉水[1] 左之利[4] 李保庆[1] 

机构地区：[1]泰山医学院化学与化学工程学院,泰安271000 [2]华东师范大学图书馆,上海200062 [3]四川大学化工学院,成都610065 [4]中国科学院上海药物研究所,上海201203

出　　处：《中国新药杂志》2009年第22期2170-2171,共2页Chinese Journal of New Drugs

摘　　要：目的:探讨合成醋柳酯的新方法。方法:以水杨酸与愈创木酚为原料,在超声波作用下合成药物醋柳酯。结果:通过与文献报道路线的对比,可知在超声波作用下合成此药物反应时间由原先的6.0 h缩短到3.5 h、产率由43.8%提高到46.7%。结论:此法在合成药物醋柳酯时,能够使合成时间缩短且产率提高。Objective：To develop a new method for synthesis of guaiaspir.Methods：A new synthetic method for guaiaspir was established by the treatment of salicylic acid and guaiacol under ultrasound.Results：This new synthesis method would shorten reaction time from 6.0 h to 3.5 h,and the yield would be increased from 43.8% to 46.7%.Conclusion：This new synthesis method is feasible to prepare guaiaspir.

关 键 词：醋柳酯 水杨酸 合成 

分 类 号：R971.1[医药卫生—药品]