阔叶五层龙的化学成分研究(英文)  

Study on Chemical Constituents from Salacia amplifolia

作　　者：濮江[1] 冯锋[1,2] 郭青龙 谢宁[1] 

机构地区：[1]中国药科大学天然药化教研室,南京210009 [2]江苏省肿瘤发生与干预重点实验室,南京210009

出　　处：《中国现代应用药学》2009年第11期916-918,920,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的对阔叶五层龙所含化学成分进行研究。方法应用液-液萃取及多种柱层析方法进行化学成分的分离、纯化,并利用多种光谱技术进行结构的分析鉴定。结果从阔叶五层龙植物中分离得到9个化合物:2-hydroxyfriedelan-3-one(1),软木三萜酮(2),lup-20(29)-en-3,21-dione(3),D-friedoolean-14-en-3-one(4),3-(3′′,4′′-dihydroxy-trans-cinnamoyloxy)-D-friedoolean-14-en-28-oic acid(5),3,22-dioxo-29-normoretane(6),羽扇豆醇(7),β-谷甾醇(8),β-胡萝卜苷(9)。结论该9个化合物均为首次从阔叶五层龙中分离得到。OBJECTIVE To investigate the chemical constituents of Scdacia amplifolia. METHODS The chemical constituents were isolated and purified by silica gel and Sephadex LH-20 column chromatography, their structures were elucidated by chemical and spectral methods. RESULTS Nine compounds were isolated and their structures was determined as 2- hydroxyfriedelan-3-one （I）, friedelin （2）, lup-20 （29）-en-3, 21-dione （3）, D-friedoolean-14-en-3-one （4）, 3-（3＂, 4＂-dihydroxy-transcinnamoyloxy）-D-friedoolean-14-en-28-oic acid （5）, 3, 22-dioxo-29-normoretane （6）, Lupeol （7）, β-Sitosterol （8）, β-Daucosterol （9）. CONCLUSION Compounds 1-9 are isolated for the first time from the plant.

关 键 词：阔叶五层龙 化学成分 三萜类化合物 

分 类 号：R284.1[医药卫生—中药学]