经皮腔内冠状动脉成形术中缺血预适应对C反应蛋白、肌钙蛋白I的影响  

Ischemic preconditioning in percutaneous transluminal coronary angioplasty and its influences to piasma troponin I and C-Reactive Protein

作　　者：李猛[1] 甘甜[2] 

机构地区：[1]内蒙古包头市中心医院心内科,内蒙古包头市014040 [2]内蒙古医学院研究生院,内蒙古呼和浩特010000

出　　处：《现代生物医学进展》2009年第19期3696-3698,共3页Progress in Modern Biomedicine

摘　　要：目的:通过测定常规经皮冠状动脉血管成形术及支架植入术(PCI)组及缺血预适应处理组术前、术后患者肌钙蛋白(ICTnI)、C-反应蛋白(CRP)的变化,以探讨缺血预适应对术中心肌缺血耐受程度及术后cTnI、CRP的影响。方法:首先设定缺血预适应(IP)方案,观察IP组患者51例、常规PCI组(CP组)患者53例术后CRP、CTnI、SvO2的变化以及术中不良事件发生与否。结果:IP组术前、术后C-反应蛋白(CRP)、肌钙蛋白(ICTnI)的变化程度低于CP组,存在显著性差异(P<0.05)。IP组术中发生心绞痛及ECG ST段缺血型改变的几率低于常规PCI组,存在显著性差异(P<0.05)。结论:缺血预适应方案可以作为PCI操作的常规方法,它可以减轻介入操作对心肌细胞的损伤,降低冠脉介入术中、术后的不良事件的发生。Objective：For the purpose of researching ischemic preconditioning（IP） in percutaneous transluminal coronary angioplasty（PTCA） and its influences to cardiac troponin I（cTnI） and C-Reactive Protein changes after PTCA treatment.Methods： PTCA was successfully performed in 104 patients,51 of them were pretreated with IP.The clinical and electrocardiographic responses to coronary occlusion induced by balloon inflation were examined.Blood samples were drawn successively from venous before and after PTCA treatment. Results： The results showed that in the IP group, compared with the CP group, was characterized by less subjective angina discomfort（P〈0.05）, less ST segment shift （P〈0.05）. In addition, in the IP group, there were no significant difference between the cTnI and CRP leves before and after PTCA treatment.In CP group were significant difference between the cTnI and CRP leves before and after PTCA treatment （P〈0.05）. Conclusions： The conclusion was that isehemic preconditioning not only improved clinical and electrocardiographic evidences but also affect the plasma CRP and cTnI leves.

关 键 词：经皮冠状动脉血管成形术及支架植入术(PCI) C-反应蛋白(CRP) 肌钙蛋白-I(cTnI) 

分 类 号：R541.4[医药卫生—心血管疾病]