系统性红斑狼疮与细胞因子的研究进展  

Advances of study on systemic lupus erythematosus and cytokine

作　　者：张曲矗[1] 陆进明[1] 

机构地区：[1]皖南医学院弋矶山医院风湿免疫科,安徽芜湖241000

出　　处：《现代生物医学进展》2009年第19期3794-3797,共4页Progress in Modern Biomedicine

摘　　要：系统性红斑狼疮(SLE)属系统性自身免疫病,以B淋巴细胞高度活化为特征,产生大量自身抗体与免疫复合物导致组织器官损害,但其致病机制仍未阐明。研究发现Th1/Th2细胞亚群及细胞因子在其发病的过程中发挥着重要的作用,细胞因子的异常表达将有助于判断疾病活动程度及指导临床免疫治疗。本文就以下几种细胞因子IL-10,IL-12,IL-18,IFN-γ,IL-17,IL-6的研究进展作一综述。Systemic lupus erythematosus（SLE）is a systemic auto-immune disease.The character is Severe activation of B lymphocyte,by producing massive antibody and immune complex which damage tissue and organ.pathogenic mechanism of SLE has no known,but recent studies have discovered Th1/Th2 cell subgroup and cytokine has an important role in process of invasion.The abnormal expression of cytokine will conduce to judge level of disease activity and guide clinical immunotherapy.The article summarized research advancemen...

关 键 词：系统性红斑狼疮 细胞因子 TH1/TH2 

分 类 号：R593.24[医药卫生—内科学]