常用抗精神病药物与血清ALT的相关性研究  

THE RELEVANCE OF RESEARCH OF ANTIPSYCHOTIC DRUGS COMMONLY USED AND SERUM ALT

作　　者：彭和平 周运芳[2] 何文 曾顺山 彭新英[3] 

机构地区：[1]江西古安市第三人民医院检验科,吉安 343000 [2]江西吉安市第三人民医院药剂科 [3]江西吉安市第三人民医院护理部

出　　处：《现代预防医学》2009年第23期4600-4600,F0003,共2页Modern Preventive Medicine

摘　　要：[目的]观察抗精神病药物与血清丙氨酸氨基转移酶(ALT)异常的关系。[方法]观察265例门诊ALT正常的精神分裂症患者住院后单一使用抗精神病药1个月后的ALT情况,并定期观察变化情况。[结果]抗精神病药物引起患者轻重不等的肝功能损害,临床上以使用一代抗精神分裂药物对血清丙氨酸氨基转移酶(ALT)升高明显,而二代药物利培酮对肝损伤较小(P﹤0.01)。[结论]对单一服用抗精神病药的精神分裂患者,应定期进行肝功能检测,发现ALT升高致肝功能异常者,应及时应用保肝护肝药物,并推荐使用副作用较小的利培酮治疗。[Objective]To observe the abnormal relationship of antipsychotics and serum alanine aminotransferase （ALT）. [Methods] 265 schizophrenia cases with normal ALT in clinic service being hospitalized were observed about the ALT situation and the changes on a regular basis after a month of a single use of antipsychotic drugs. [Results] Various severities of liver function damages caused by antipsychotic drugs in patients were found. In clinical use, the first-generation of anti-schizophrenia drug made serum alanine aminotransferase （ ALT） increase significantly, while the second-generation drug （risperidone） had lighter liver injury （ P﹤0.01）. [ Conclusion] A single use of antipsychotic drugs in patients with schizophrenia should be elevated ALT-induced liver dysfunction through regular liver function tests. It should use the drugs for protection of liver in a timely manner and recommend the use of smaller side-effects like isperidone.

关 键 词：抗精神病药物 ALT 相关研究 

分 类 号：R446.11[医药卫生—诊断学] R971.4[医药卫生—临床医学]