曲美他嗪对稳定性心绞痛缺血预适应的影响  

Effect of Trimetazidine(TMZ) in Patients with Stable Exertional Angina Protection Afforded by Ischemic Preconditioning

作　　者：彭志坚[1] 蔡建生[1] 李继锋[1] 章少波[1] 

机构地区：[1]广东省汕头市第二人民医院心内科,广东汕头515011

出　　处：《河北医学》2009年第12期1416-1419,共4页Hebei Medicine

摘　　要：目的:探讨曲美他嗪对稳定性劳力型心绞痛患者缺血预适应保护作用的影响。方法:64例稳定性劳力型心绞痛患者随机分为A组(n=32)及B组(n=32):A组为常规药物治疗;B组为常规药物治疗基础上,加用曲美他嗪20mg每日3次,治疗12周。观察两组治疗前后运动平板试验结果,比较两组的疗效。结果:两组治疗前后自身比较每周心绞痛发作次数、运动耐量、运动诱发心绞痛所需时间、运动至ST段压低1 mm所需时间及运动持续时间均有显著统计学差异(P<0.05);治疗后组间比较运动耐量、每周心绞痛发作次数、运动诱发心绞痛所需时间、运动至ST段压低1 mm所需时间及运动持续时间B组明显优于A组(P<0.05)。结论:曲美他嗪能提高稳定性劳力型心绞痛患者的缺血阈值,增加缺血预适应保护作用。Objective： To study the effect of trimetazidine （ TMZ ） in patients with stable exertional angina protection afforded by ischemic preconditioning （IP ）. Method： 64 proven stable exertional anginal patients were randomly divided into group A （ n = 32 ） and group B （ n = 32 ）. The conventional treatments were given to each group, and at the same time TMZ （ 20 mg Tid ） was added to group B. The treatment lasted 12 weeks. Then, the results of treadmill tests were analyzed. Result： Both groups, the above - mentioned indexes were changed with significant difference （ P 〈 0.05 ） after treatments. Compared between the two groups after the trial by the exercise tolerance, times of angina petoris attacked every week, time for inducing angina by exercise and time for inducing 1 mm ST - segment depression by exercise, the total exercise time in group B were superior to those in group A （ P 〈 0.05 ）. Conclusion： For patients with stable exertional angina, TMZ could make myocardium a higher ischemic threshold and increase the protection afforded by ischemic preconditioning.

关 键 词：心绞痛 曲美他嗪 缺血预适应 

分 类 号：R541.4[医药卫生—心血管疾病]