299例药源性血糖异常分析  

Analysis of 299 cases of drug-induced pathoglycemia

作　　者：杨沈雷[1] 杨晓[1] 范淑青[2] 

机构地区：[1]广州医学院港湾医院,510700 [2]武警广东省总队医院

出　　处：《中国现代药物应用》2009年第23期12-15,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨药源性血糖异常的特点和规律,促进临床合理用药。方法检索1998～2008年中国医院数字图书馆CNKI期刊知识库收载的中英文医药卫生期刊,对其报道的药源性血糖异常个案进行统计与分析。结果引起血糖异常的药物种类前3位是:激素及其相关药物118例(39.46%)、抗微生物药物71例(23.74%)、抗肿瘤药物30例(10.03%);而位居前3位的药品分别是:格列本脲52例(17.39%)、加替沙星49例(16.39%)左旋门冬酰胺酶26例(8.70%)。激素及其相关用药118例,(39.46%)、抗微生物药物71例(23.74%)、抗肿瘤药30例(10.03);位居前3位的药品分别是格列本脲52例(17.39%)、加替沙星49例(16.39%)、左旋门冬酰胺酶26例(8.70%)。结论应严格用药指征,重视药物引起血糖异常的现象,加强对患者血糖监测,以减少药源性血糖异常的发生,确保用药安全。Objective To discuss the characteristics and regularity of drug-induced pathoglycemia so as to promote the rational use of drugs in the clinic. Methods The case reports on drug-induced pathoglycemia retrieved from Chinese medical and English medical science periodicals from 1998 to 2008 collected in CNKI periodicals knowledge base in China hospital digital library were analyzed statistically. Results The drugs that induced athoglyeemia were included chiefly hormone and relate drugs （118cases, 39.46% ） , antimicrobial-drugs （71 ases,23.74% ） and antititumor drugs （30cases, 10. 03% ） ; glihenclamide was reported mostly （52 cases, 17.39% ） , the next was gatifloxacin（49cases, 16.39% ）and the third was L-Asparaginase （26 cases, 8.70% ）. Conclusion An indispensable measure to reduce drug-induced disease and its pathoglycemia rate is to strictly control the indications of medication and strengthen the monitor of the level of patient＇ s blood sugar in use the drug, to make sure of the safety of the drug.

关 键 词：血糖异常 合理用药 

分 类 号：R587.1[医药卫生—内分泌] R595.3[医药卫生—内科学]