抗癫痫新药Carisbamate  

Carisbamate,a novel antiepleptic drug

作　　者：徐佳骏[1] 刘晓琰[1] 

机构地区：[1]上海交通大学医学院附属仁济医院药剂科,上海200127

出　　处：《中国新药杂志》2009年第21期2011-2013,共3页Chinese Journal of New Drugs

摘　　要：Carisbamate作为新型的神经调质,在动物实验中表现出广谱抗癫痫活性,现有的临床研究表明,该药对癫痫部分性发作和光敏性癫痫有一定的疗效,且耐受性良好,与一些抗癫痫药物合用时不发生具临床意义的相互作用,可能成为临床上有前景的抗癫痫药物。现综述其药理作用、临床研究、不良反应等。Carisbamate is a novel neuromodulator that has displayed its favorable antiepileptic effect in a broad spectrum of animal seizure models.Current studies show it can be used to partial-onset seizures and photoparoxysmal responses.It appears to be generally well tolerated.There are no clinically significant interactions between carisbamate and some antiepileptic drugs.Carisbamate may become a prospective antiepileptic drug in clinical use.

关 键 词：抗癫痫药物 CARISBAMATE 药动学 临床研究 安全性 

分 类 号：R971.6[医药卫生—药品]