高三尖杉酯碱乳膏体外透皮吸收作用研究  

Perceutanous Absorption of Homoharringtonine Ointment in Vitro

作　　者：赵维娟[1] 黄通瑞[2] 张梅[1] 

机构地区：[1]北京军区总医院药理科,100700 [2]解放军白求恩国际和平医院内科,石家庄050082

出　　处：《医药导报》2009年第12期1554-1555,共2页Herald of Medicine

摘　　要：目的探讨高三尖杉酯碱乳膏体外透皮吸收作用。方法采用小鼠体外皮肤作为渗透屏障,研究不同浓度氮酮对高三尖杉酯碱促渗作用的影响。结果氮酮可显著提高高三尖杉酯碱对皮肤的渗透作用,含2%和5%氮酮的乳膏渗透速率比空白乳膏分别增加了56.88%和89.51%。结论高三尖杉酯碱乳膏具有良好的皮肤渗透性,5%氮酮对其促渗效果最好。Objective To study the perceutanous absorption of homoharringtonine ointment in vitro. Methods Rats skin was applied as absorption barrers to study influence of azone at different concentrations on homoharringtonine permeation. Results Azone enhanced skin permeation of homoharringtonine significantly. Compared with the blank ointment, the steady pereutanous absorption rate of homoharringtonine ointment containing with 2% and 5% azone increased by 56. 88% and 89.51%, respectively. Conclusion Homoharringtonine cream have a good percutanous permeability, and 5% azone is the best permeating accelerator.

关 键 词：高三尖杉酯碱 乳膏 透皮吸收 氮酮 

分 类 号：R979.1[医药卫生—药品] R965[医药卫生—药学]