桔梗皂苷胶囊制备工艺的实验研究  

Study on Preparation Technique of Jiegeng Zaogan Capsules

作　　者：陈勤[1] 陈尘[1] 吕凌[2] 崔颖[2] 王艳[2] 

机构地区：[1]安徽大学生命科学学院,安徽省中药研究与开发重点实验室,合肥230039 [2]安徽省药物研究所,合肥230022

出　　处：《中药新药与临床药理》2009年第6期576-580,共5页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：安徽省教育厅自然科学研究项目(KJ2009A116);国家大学生创新性实验项目(NO.081035701)

摘　　要：目的研究桔梗皂苷胶囊的制备工艺。方法以桔梗皂苷D含量为检测指标,应用L9(34)正交试验设计对桔梗皂苷胶囊进行最佳制备工艺筛选。结果最终得到桔梗皂苷胶囊的最佳提取工艺为:加水提取3h、提取3次、加水量10倍、醇沉浓度为65%,药醇液静置48h。结论该工艺制备可靠,质量稳定,适合于工业化生产。Objective To study the preparation technique for Jiegeng Zaogan capsules （capsules of total saponins from the roots of Platyeodon grandiflorum A. DC）. Methods The optimal preparation technique for Jiegeng Zaogan capsules was investigated by L9 （3^4） orthogonal test with the Platycodin D content as the observation index. Results The optimized extraction procedure was as follows： extracting for 3 hours each time and 3 times in total, adding 10 - fold water, alcohol sedimentation concentration at 65 % , and alcohol sedimentation solution staying for 48 hours. Conclusion The preparation process of Jigeng Zaogan capsules is reliable with stable quality, which offers a feasible method for the industrialization production of the capsules.

关 键 词：桔梗皂苷胶囊 桔梗皂苷D 制备工艺 正交试验 高效液相色谱 

分 类 号：R284[医药卫生—中药学] TQ460.6[医药卫生—中医学]