富路通治疗血管性痴呆的临床研究  

Clinical Study of Fulutong on Treatment of Vascular Dementia

作　　者：刘杰[1] 

机构地区：[1]内蒙古民族大学附属医院神经内科,内蒙古通辽028000

出　　处：《医药世界》2009年第1期11-12,共2页Medicine World

摘　　要：目的:对富路通治疗血管性痴呆的临床疗效做进一步探讨。方法:本资料纳入病例54例,遵循随机分组方案,治疗组28例(富路通治疗组),对照组(吡拉西坦治疗组)26例,进行为期6个月的随访观察。治疗前及治疗后每8周记录1次MMSE、BRS指标评分。治疗前及治疗6个月末各进行一次实验室检查,以评定其临床安全性。结果:富路通和吡拉西坦治疗后患者MMSE积分增加有统计学意义(P<0.05),BRS行为量表评分的减分变化有统计学意义(P<0.05)。治疗组和对照组的认知功能疗效有效率分别为75%、65%药物不良反应两组间无统计学差异。结论:富路通能明显改善轻、中度VD患者认知功能状态及日常生活能力,不良反应少。Objective：To evaluate the clinical efficacy of Fulutong in treatment of patients with vascular der/lentia （VD）. Methods：54 cases were completed in the clinical study ,which are divided in random into Fulutong reatment group （treatment group） 28 cases and Bilaxitan treatment （control group） 26cases. The duration was 36 weeks. The scales of MMSE was used at outset and the end of 36 weeks ; The scales of BRS was used at outset and the end of every 6weeks ; The follow up duration was 6 ,months after excellence. Results：In clinical efficacy,MMSE scores of patients after treatment were significantly increased than before（P〈0.05）, the scores of BRS dropped ,the changes were statistically significant （P〈0.05）. The cognitive function efficiency of the treatment group was 75%, 65 % of the control group. Con- clusions：Fulutong can improve the cognitive function state and the lower state of daily living of vascular dementia （P〈0. 05）, the effict of Fulutong is considered similar to hydergine＇s.

关 键 词：痴呆 血管性/药物疗法 尼麦角林/治疗应用 血管舒张药/治疗应用 

分 类 号：R543[医药卫生—心血管疾病]