黏液型和非黏液型铜绿假单胞菌耐药性比较  

Comparison of drug resistance between mucoid and non-mucoid Pseudomonas aeruginosa

作　　者：孙淑红[1] 胡晓峰[1] 刘晓红[1] 朱德全[1] 

机构地区：[1]山东省临沂市人民医院临床检验中心,276003

出　　处：《中华临床感染病杂志》2009年第6期345-348,共4页Chinese Journal of Clinical Infectious Diseases

摘　　要：目的比较黏液型和非黏液型铜绿假单胞菌在体外药物敏感性试验中对各种药物的耐药性。方法采用VITEK-32全自动细菌鉴定系统及配套的GNI^＋、GNS-448和E-test、K—B纸片等方法对菌株进行鉴定和药物敏感性试验，并用x^2检验进行统计学分析。结果黏液型铜绿假单胞菌在体外药物敏感性试验中对亚胺培南、左氧氟沙星、美洛培南、头孢匹肟、头孢哌酮／舒巴坦、阿米卡星、庆大霉素、哌拉西林／他唑巴坦、头孢他啶和头孢噻肟的耐药率分别为5，3％、16．1％、5．6％、20．6％、1．1％、10．5％、26．9％、5．3％、31．5％和60．2％。除头孢他啶外，黏液型铜绿假单胞菌耐药率均显著低于非黏液型铜绿假单胞菌（P值〈0．05或0．01）。结论与非黏液型铜绿假单胞菌相比，黏液型铜绿假单胞菌的体外耐药性较弱。Objective To compare the drug resistance of nmcoid Pseudomonas aeruginosa with that of non-mucoid. Methods All specimens isolated and cultured from patients were identified and the antibiotic sensitivity was tested by automatic microorganism analyzer VITEK-32, GNI ＋ , GNS-448, E-test and K-B. Results Drug resistant rates of mucoid Pseudomonas aerttginosa to imipenem, levofloxacin, meropenem, cefepime, cefoperazone/sulbactam, amikacin, gentamicin, piperacillin-tazobactam, ceftazidime and cefotaximewereS. 3%, 16. 1%, 5.6%, 20.6%, 1.1%, 10.5%, 26.9%, 5.3%, 31.5% and 60. 2% , respectively. The drug resistant rates of mucoid Pseudomortas acruginosa were lower than those of non-mucoid except to ceftazidime. Conclusion Compared with non-mucoid Pseudomortas aeruginosa, antibiotic resistance of mucoid Pseudomonas aeraginosa is weaker in vitro.

关 键 词：假单胞菌 铜绿 黏液型 非黏液型 抗药性 

分 类 号：R446[医药卫生—诊断学]