Gd-DTPA的对比度增强作用与时间的关系  

Gd-DTPA:The Relationship Between Contrast-enhanced Effect and Time

作　　者：黄继英[1] 张明[1] 方明[1] 戴波 

机构地区：[1]西安医科大学第一临床医学院医学影像中心

出　　处：《实用放射学杂志》1998年第10期596-598,共3页Journal of Practical Radiology

摘　　要：目的：研究Ｇｄ－ＤＴＰＡ的对比度增强作用与时间的关系，提高ＭＲＩ中使用Ｇｄ－ＤＴＰＡ的有效性和诊断作用。方法：６例颅内病变，按标准剂量注射Ｇｄ－ＤＴＰＡ后进行增强成像，获取注射后不同时间开始采集的Ｔ１加权影像，并测量ＲＯＩ中的信号强度。结果：注射后０～２０ｍｉｎ的影像上出现增强的病变区，延至３０～１１０ｍｉｎ仍显示增强现象。在信号测量的基础上描绘了几种病变的信号增强程度与时间的关系曲线。结论：Ｇｄ－ＤＴＰＡ增强ＭＲＩ的信号采集可在注射Ｇｄ－ＤＴＰＡ后０～３ｈ内任意时刻开始，这为对不同临床状态的患者有效进行增强ＭＲＩ提供了灵活性。利用信号增强程度与时间的关系曲线提供的信息，可提高Ｇｄ－ＤＴＰＡ增强影像对各种病变的诊断作用。Objective:To investigate the relationship between contrast-enhancement effect and time post-Gd-DTPA,so that to advance the effectiveness and diagnostic significance of Gd-DTPA in MRI.Methods:6 patients with brain lesions were imaged by the intravenous injection of standard dose of Gd-DTPA.The T 1 weighted images were acquired at different delay time after injection,and the signal intensities in ROI were measured.Results:The area of signal enhancement in lesions occrued in 0-20 minutes after injection,it still enhanced at the delay time of 30～110 minutes after injection.Based on the signal measurement,the relative curves of signal enhancement degree and the initial time of acquisition were described for three lesion.Concluison:To perform contrast enhancement MRI by using Gd-DTPA,signal acquisition can be initialed at any time within 0-3 hours after injection of Gd-DTPA.This fact provides flexibility in effectively performing Gd-DTPA enhanced MRI for patients of various clinical conditions.With the information acquired by the relative curves of signal intensity and time,the significance of Gd-DTPA enhanced MRI in differential diagnosis can be advanced.

关 键 词：钆 二乙烯五胺乙酸 NMR 成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]