颅脑损伤后血清垂体前叶激素的变化  

The changes in blood pituitary hormones in the patients with craniocerebral trauma

作　　者：丁雁[1] 龚德生[1] 李璐[1] 朱江[1] 牟琴峰[1] 樊惠芳[1] 

机构地区：[1]苏州医学院附属第三医院,213003

出　　处：《中华实验外科杂志》1998年第6期526-527,共2页Chinese Journal of Experimental Surgery

摘　　要：目的探讨颅脑损伤对内分泌功能的影响。方法应用磁性酶联免疫定量分析法,对颅脑损伤后血清催乳素(PRL)、促卵泡生成素(FSH)、促黄体生成素(LH)、促甲状腺素(TSH)做定量分析。结果(1)与正常人(88例)相比,颅脑损伤后(134例)血清PRL和FSH显著增高,P<0.0001。LH和TSH未见显著变化。(2)伤后24、48、72小时动态观察(32例),发现伤后24小时内PRL、FSH和LH有显著增高,48和72小时显著下降,P<0.01～0.001。TSH未见显著性变化。结论颅脑损伤后对垂体前叶激素分泌有影响,主要是PRL显著增高。Objective To investigate the influence of crantocerebral trauma on the blood pituitary hormones. Methods By using enzyme immunoassay (magnetic solid phase) technique, the levels of prolactin (PRL), follicle stimulating hormone (FSH), luteninizing hormone (LH), and thyroid stimulating hormone (TSH) were determined. Results The levels of PRL and FSH were significantly raised in the patients with craniocerebral trauma (134 eases) as compared with in normal controls (88 cases, P<0. 01). No obvious change was found in LH and TSH levels. Twenty-four h after the trauma (32 cases), the levels of PRL, FSH, and LH were much higher than those in 48 h and 72 h after the trauma (P<0. 01～0. 001). No significant change was found in TSH. Conclusion Craniocerebral trauma could influence the ptuitary function, mainly presenting the increase of PRL level.

关 键 词：颅脑损伤 垂体前叶激素 磁性酶联免疫 

分 类 号：R651.15[医药卫生—外科学]