Design and Synthesis of New Anti-AIDS Drugs——Introducing an Immunomodulator into Delavirdine Derivative  

作　　者：LU Hai-bin MI Hao-yu CUI Lin-lin YU Xiang-Hui LIANG Tie WANG En-si 

机构地区：[1]College of Life Science [2]School of Pharmacy, Jilin University, Changchun 130021, P. R. China [3]Affiliated Hospital, Changchun Chinese Medicine Universily, Changchun 130061, P. R. China

出　　处：《Chemical Research in Chinese Universities》2009年第6期856-860,共5页高等学校化学研究（英文版）

基　　金：Supported by Scientific and Technological Development Program Foundation of Jilin Province,China(No.20020503-11)

摘　　要：In consideration of the anti-HIV activities of delavirdine, resveratrol and Pidotimod, a novel kind of anti-AIDs drug（compounds 5 and 7） was synthesized. Compound 5 was synthesized by linking the delavirdine derivative to pidotimod, compound 7 was synthesized via linking the delavirdine derivative to resveratrol with terephthalic acid as the conjugated compound by two different routes. The structures were confirmed by means of IH NMR, 13C NMR, IR, MS and elemental analysis. The results for HIV-1 reverse transcriptase assay, quantitative titration of HIV-1 by using MAGI assay and pharmacokinetics assay show that a novel kind of anti-AIDs drug has been synthesized.In consideration of the anti-HIV activities of delavirdine, resveratrol and Pidotimod, a novel kind of anti-AIDs drug（compounds 5 and 7） was synthesized. Compound 5 was synthesized by linking the delavirdine derivative to pidotimod, compound 7 was synthesized via linking the delavirdine derivative to resveratrol with terephthalic acid as the conjugated compound by two different routes. The structures were confirmed by means of IH NMR, 13C NMR, IR, MS and elemental analysis. The results for HIV-1 reverse transcriptase assay, quantitative titration of HIV-1 by using MAGI assay and pharmacokinetics assay show that a novel kind of anti-AIDs drug has been synthesized.

关 键 词：SYNTHESIS AIDS Conjugated compound 

分 类 号：TQ463.54[化学工程—制药化工] F426.7[经济管理—产业经济]