烟草暴露与肺结核发病的病例对照研究  

A case-control study on exposure to tobacco and pulmonary tuberculosis

作　　者：张学青[1] 庄斌[2] 

机构地区：[1]济宁市第一人民医院呼吸内科,山东济宁272000 [2]济宁医学院公共卫生学院,山东济宁2172013

出　　处：《中国热带医学》2009年第12期2230-2231,共2页China Tropical Medicine

摘　　要：目的探讨烟草暴露与肺结核发病的关系,揭示肺结核危险因素。方法采用病例对照设计,应用自行设计的问卷调查济宁市136例肺结核病例和149例对照的烟草暴露及其它肺结核潜在危险因素情况,并进行单因素和多因素条件Logistic回归分析。结果单因素分析显示:吸烟(OR=6.011,OR95%CI:3.648～9.905,P=0.000)和已戒烟(OR=5.125,OR95%CI:2.100～12.507,P=0.000)有统计学意义;被动吸烟(OR=1.042,OR95%CI:0.642～1.693,P=0.868)无统计学意义。多因素条件Logistic回归分析显示:吸烟(OR=6.282,OR95%CI:3.188～12.382,P=0.000)和已戒烟(OR=9.938,OR95%CI:2.851～34.634,P=0.000)均是肺结核危险因素。结论有吸烟史是肺结核发病的危险因素。Objective To study the possible relationship between exposure to tobacco and pulmonary tuberculosis for exploring the risk factors related to this disease. Methods A case-control study was conducted.Informations on exposure to tobacco and other related factors of tuberculosis were collected in 136 cases and 149 controls using a questionnaire designed by ourselves.Univariate and multivariate non-conditional logistic analyses were conducted in the end. Results Current smoking（OR=6.011 ,OR 95% CI： 3.648-9.905,P=0.000）and ex-smoking（OR=5.125,0R 95% Ch 2.100-12.507,P=：0.000） were significantly associated with pulmonary tuberculosis in univariate analyses,but there was no significant association between passive smoking and this disease（OR=1.042,0R 95% CI： 0.642-l.693,P=0.868）.Current smoking（OR=6.282,0R 95% CI： 3.188-12.382,P=0.000）and ex-smoking （OR=9.938,OR 95% CI： 2.851-34.634,P=0.000）were significantly associated with pulmonary tuberculosis in multivariate non-conditional logistic analyses after adjusting other factors. Conclusion Current smoking and ex-smoking are risk factors for pulmonary tuberculosis.

关 键 词：结核 肺 吸烟 病例对照研究 

分 类 号：R52[医药卫生—内科学]