干扰素-γ和白细胞介素-4基因多态性与支气管哮喘  

IFN-γ and IL-4 gene polymorphisms in bronchial asthma

作　　者：吴敬芳[1] 黄花荣[1] 

机构地区：[1]中山大学附属第二医院儿科,广东广州510120

出　　处：《国际内科学杂志》2009年第11期676-678,682,共4页International Journal of Internal Medicine

摘　　要：支气管哮喘是一种呼吸系统的慢性炎症性疾病,干扰素(IFN)-γ和白细胞介素(IL)-4在其发病中起重要作用。近年来有关这两种细胞因子基因多态性与哮喘相关性的研究不少。多数研究表明IFN-γ基因的CA重复序列、+874T/A和+5644A/T,IL-4基因的-589C/T和-33C/T多态性与哮喘易感性及哮喘表型存在相关性,而对IFN-γ基因-179G/T多态性的研究甚少。本文就IFN-γ和IL-4基因多态性与哮喘的关系作一综述。Bronchial asthma is a chronic inflammatory disease Interferon-3, （IFN-γ） and inteleukin-4 （ IL-4 ） play a crucial role in development of asthma. In recent years, many studies about IFN-γ and IL-4 gene polymorphisms in bronchial asthma have been performed. Most studies indicated that the CA repeat element, ＋ 874T/A and ＋5644A/T of IFN-γ gene as well as the -589C/T and -33C/T of IL-4 gene had close correlation with asthma susceptibility and asthma phenotypes, whereas there were few studies about the -179G/T polymorphism of IFN-γ gene. In this review, we summarized the association of IFN-γ and IL-4 gene polymorphisms with asthma.

关 键 词：干扰素-Γ 白细胞介素-4 基因 多态性 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]