钙离子通道与精子运动功能  

Calcium channel and sperm motility

作　　者：张瑞芳[1] 曾海涛[1] 

机构地区：[1]中南大学生物科学与技术学院分子生物学研究中心,长沙410078

出　　处：《生命的化学》2009年第6期878-882,共5页Chemistry of Life

基　　金：国家自然科学基金(No.30470892)资助

摘　　要：钙离子作为一种重要的细胞信号第二信使,在精子功能中起着重要的作用。在哺乳动物细胞质膜上存在多种钙离子通道,包括电压依赖性钙通道、精子的阳离子通道(cation channel of sperm,CatSper)、环核苷酸门控通道、瞬时感受器电位通道、钙释放通道等。由这些钙离子通道调节的钙离子流动在精子功能中起重要作用,任意一类通道的失活都会导致精子功能的下降。本文主要综述近年来与精子功能有关的钙离子通道的研究进展。Ca^2＋ is an important cellular second messenger, which plays crucial role in sperm function. There are many Ca^2＋ channels on plasma membrane in mammalian, such as voltage-dependent calcium channel, CatSper channel, cyclic nucleotides voltage-gated channel, transient receptor potential channel and calcium release channel etc. The affluxion of Ca^2＋ has significant effects on sperm function which is regulated by the Ca^2＋ channel. The sperm function can be breakdown with any channel inactivation. This review reports the recent development of investigation on Ca^2＋ channel of sperm function.

关 键 词：钙离子 钙离子通道 精子运动 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]