双足鼠脊柱侧凸模型手术方法改良  

Modified surgical procedures in rat scoliosis model

作　　者：王储[1] 郝东升[1] 段圆慧[1] 吴志宏[1] 邱贵兴[1] 

机构地区：[1]中国医学科学院北京协和医院骨科,100730

出　　处：《中华实验外科杂志》2009年第12期1732-1733,F0004,共3页Chinese Journal of Experimental Surgery

摘　　要：目的双足鼠脊柱侧凸模型是一种理想的脊柱侧凸动物模型。目前建模手术方法死亡率较高。本研究拟从手术方法上探究提高建模手术成功率的方法。方法在15只1个月龄大鼠中，采用双上肢去神经和右侧肋骨栓系（4-0无创缝线）法建模，术中不分离脊旁肌。观察死亡率。结果术中肋骨栓系时，所有大鼠膈肌活动良好，未出现气胸或大血管损伤。无大鼠在手术中或术后一周内死亡。结论建模术中不分离脊旁肌、右侧肋骨栓系和栓系用4旬无创缝线，成功使得建模手术死亡率降为零，是一种较好的手术方法。Objective Bipedal rat is an ideal animal model in researching scoliosis. However, high mortality remained in current surgical procedures leading to a high rate of failure. Methods Fifteen rats were subjected to the operation of denervation in upper limbs and tethering ribs on the right side using 4-0 non-invasive stitch, and the erector muscle of spine was reserved during the operation. One-week mortality was calculated. Results No complications were observed in the surgical procedures, and no rat died during or after the operation. Conclusion Reservation of the erector muscle of spine and tethering ribs on the right side using 4-0 non-invasive stitch can make the mortality of the operation decline to zero.

关 键 词：脊柱侧凸 模型 动物 手术方法 

分 类 号：R687.3[医药卫生—骨科学] R-332[医药卫生—外科学]