中药清胰汤对犬急性坏死性胰腺炎肠粘膜损伤修复的影响  

EFFECTS OF CHINESE MEDICINE “QING YI TANG” ON REPAIR OF INTESINAL MUCOSA INJURY IN ACUTE NECROTIZING PANCREATITIS

作　　者：吴承堂[1,2] 黎沾良[1,2] 

机构地区：[1]第一军医大学南方医院普外科 [2]北京解放军304医院普外科

出　　处：《中国普外基础与临床杂志》1998年第6期326-328,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：为观察中药清胰腺对急性坏死性胰腺炎（ＡＮＰ）犬肠粘膜损伤修复的作用，经主胰管注入牛磺胆酸钠和胰蛋白酶复制犬ＡＮＰ模型，观察ＡＮＰ时及中药清胰汤治疗后肠粘膜组织结构的变化，肠组织蛋白、丙二醛（ＭＤＡ）含量及二胺氧化酶活性（ＤＡＯ）改变，肠通透性变化，检测血中内毒素水平，并做脏器细胞培养。结果发现，经中药清胰汤治疗后，ＡＮＰ犬的肠粘膜损害明显减轻，肠粘膜绒毛宽度、高度和面积显著增加，肠组织蛋白含量增加，肠通透性显著下降，血中内毒素水平下降１～２倍，脏器细菌移位率减少５０％。本实验结果提示：中药清胰汤能显著减轻犬ＡＮＰ时肠粘膜的损伤，保护肠屏障功能。The purpose of the study was to observe effect of chinese medicine “Qing Yi Tang” on the repair of injury of intestinal mucosa in acute necrotizing pancreatitis (ANP). Dogs ANP model were induced by injection of 5% sodium taurocholate (0.5 ml/kg) with 3 000 u/kg trypsin into the pancreatic duct. Diamine oxidase and anylase activity in blood, protein and MDA levels of ileal mucosa were to be determined in ANP and after treatment of “Qing Yi Tang”. Intestinal permeability was also to be studied, LPS and bacteria translocation (BT) were obseved. All animals were sacrificed on day 7, the tissue of ileal mocosa was collected for histological and ultrastructural studies. The results showed that after treatment with Chinese medicine “Qing Yi Tang”, the injury of intestinal mucosa in ANP reduced. The length, height, area and protein of ileal mucosa increased significantly, intestinal permenbility decreased, the levels of LPS reduced in 1-2 times, and organ BT rate also reduce in 50%. The results indicated that chinese medicine “Qing Yi Tang” had good effect on improving repair of intestinal mucosa injury, protecting gut barrier function, reducing the incidence of LPS and bacteria translocation.

关 键 词：急性 坏死性胰腺炎 肠粘膜损伤 清胰汤 修复 

分 类 号：R269.575.1[医药卫生—中西医结合]