细胞色素P450s代谢手性化合物研究进展  

Advances in Chiral Compounds Metabolized by Cytochrome P450s

作　　者：熊明瑜[1] 刘惠君[2] 谢飞[2] 

机构地区：[1]浙江大学环境科学研究所,杭州310029 [2]浙江工商大学环境科学与工程学院,杭州310012

出　　处：《科技通报》2009年第6期727-731,共5页Bulletin of Science and Technology

基　　金：国家自然科学基金项目(20677049)

摘　　要：综述了细胞色素P450s(CYP450s)对手性化合物代谢的对映体选择性差异,探讨了CYP450s酶工程研究的进展。在环境科学方面,研究CYP450s代谢环境中手性污染物的选择性可为正确评价手性污染物及其产物的毒理作用并为环境中手性污染物的生物修复提供依据。The enantioselective metabolism of chiral compounds by Cytochrome P450s were reviewed in this paper.The current development of engineering CYP450s enzymes were also discussed.The research of the selective metabolism of chiral pollutions by CYP450s is very important in environmental science,especially to estimate the toxicology of chiral pollutions and their metabolic products.The research will also provide the theories for chiral pollutions bioremediation.

关 键 词：细胞色素P450s 手性化合物 对映体选择性 

分 类 号：O641.6[理学—物理化学]