清胆利湿汤(丸)的临床与实验研究  

Clinic and Experimental Study of Qingdan Lishi Tang ( Wan)

作　　者：佘靖[1] 张炳厚[1] 刘红旭[1] 谢幼红[1] 王斌[1] 邓新荣[2] 金敬善[2] 周萍[2] 赵子厚[2] 胡昕 

机构地区：[1]北京中医医院,北京100010 [2]北京市中医研究所,北京10001 [3]北京市鼓楼中医医院,100007

出　　处：《中国医药学报》1998年第5期19-23,共5页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：本文全部病例共47例。对符合入选病例标准者,予清胆利湿丸,对症状较重者,先予清胆利湿汤,获效后改清胆利湿丸。4周疗程结束时,临床治愈16例,显效16例,有效12例,无效3例,总有效率93.62％。25例患者测定了血浆ET(内皮素)、NO氧化氮)水平,19例患者测定了血浆GC(甘胆酸)水平。结果,患者血浆ET水平与正常人比较未见明显差异,NO、GC水平明显高于正常人水平。10例获效患者血浆NO、GC水平有所下降,接近正常人水平(p>0.05); ET水平亦有所下降,但未见统计学差异。Qingdan Lishi Wan was given to those patients who suffered from cholecystitis, Qingdan Lishi Tang was given to those severe patients then substituted for Qingdan Lashigiven Wan after being achieved effect. After 4 courses of treatment, 16 cases were cured, 16 cases showed marked effect, 12 cases showed effect, 3 cases were no effect, the total effect rate was 93. 62%. Of all patients, 25 cases' plasma endotholin (ET) and nitric oxide (NO) were determined, and 19 cases' plasma glycochoio acid (GC) was also determined, the re- suits showed that patients plasma ET has no significantly change as comparing to those normal person, the level of plasma NO and GC was remarked higher than that of normal. After treatment, 10 cases' plasma NO and GC decreased to the normal level (P < 0. 05), ET also decreased but with no statistical difference. During the treatment, no side effects have been observed, acute toxicity test also showed no marked toxicity. The mouse tolerance showed good with LD50 > 232. 0 g, corresponding to the 60 times of Clinic dosage, which indicated that Qingdan Li Shi Tang (Wan) was a Safety and efficacious drug.

关 键 词：中医药疗法 胆囊炎 清胆利湿汤 

分 类 号：R259.756.1[医药卫生—中西医结合] R285.6[医药卫生—中医内科学]