针刺对老化痴呆鼠脑兴奋性氨基酸水平影响的实验研究  

Effect of Acupuncture on Levels of Excitatory Amino Acids in the Brain of SAM-P/8 Senile Rats

作　　者：石学敏[1] 韩景献[1] 李平[1] 赵俊宏[1] 王舒[1] 刘庆忠[1] 杨增瑞 来丽萍 赵立荣 

机构地区：[1]天津中医学院第一附属医院老年病研究室,300193

出　　处：《中国针灸》1998年第11期689-692,共4页Chinese Acupuncture & Moxibustion

基　　金：天津市八五攻关课题 (课题号 :910 0 9110 2 2 )

摘　　要：在观察快速老化痴呆模型小鼠 ( SAM-P/ 8)不同脑区 EAAS和 IAAS水平的基础上 ,重点研究了针刺对 EAAS代谢的影响。结果表明 ,与正常老化 SAM-R/ 1鼠比较 ,P/ 8海马、皮层及纹状体的 EAAS合成及降解均处于亢进状态 ,IAAS亦存在一定程度的改变。针刺可以明显降低异常升高的 Glu及 Gln、Asn水平 ,提示针刺具有调整 EAAS代谢的作用。研究表明兴奋性氨基酸毒性在老化痴呆的发病机制中起重要作用 ,针刺对Levels of excitatory and inhibitory amino acids in different brain regions and effect of acupuncture on metabolism of excitatory amino acids in the mouse of rapidly aging and dementia(SAM P/8)were observed Results indicated that synthesis and degradation of excitatory amino acids in the hippocampus,cortex and striatum in P/8 rats were at hyperfunctional state and inhibitory amino acids changed to a certain extent as compared with the normally aging rats(SAM R/1);acupuncture could decrease obviously the abnormal increase of glutamic acid,glutamine and asparagine It is suggested that acupuncture has regulative action on metabolism of excitatory amino acids,and toxicity of excitatory amino acids play an important role in pathologic mechanisms of aging and dementia,and regulative action of acupuncture on excitatory amino acids may be one of important mechanisms treating aging and dementia

关 键 词：老年性痴呆 氨基酸代谢 针刺疗法 

分 类 号：R246.6[医药卫生—针灸推拿学] R277.791.6[医药卫生—中医临床基础]