4-(2'-氟-4'-氰基苯氧基)苯酚的合成新方法  

New Synthesis Technique of 4-(4’-cyano-2’-fluorophenoxy) Phenol

作　　者：闫潇敏[1] 宁斌科[1] 王列平[1] 张媛媛[1] 朱利民[1] 

机构地区：[1]西安近代化学研究所,陕西西安710065

出　　处：《化学与粘合》2009年第6期73-75,共3页Chemistry and Adhesion

摘　　要：4-(2'-氟-4'-氰基苯氧基)苯酚是合成苯氧丙酸类高效除草剂的重要中间体。研究了4-(2'-氟-4'-氰基苯氧基)苯酚合成的新方法。该方法以3,4-二氟苯腈和对羟基苯甲醚为主要原料,首先合成4-(2'-氟-4'-氰基苯氧基)苯甲醚,再经三溴化硼还原得到4-(2'-氟-4'-氰基苯氧基)苯酚。通过红外、核磁及质谱等分析手段对其化学结构进行了鉴定,两步反应总收率为64%,产品纯度95.2%,克服了文献报道的合成方法产量小、收率低的缺点。4-（4＇-cyano-2＇-fluorophenoxy） phenol is an important intermediate of phenoxypropionate herbicide. The new synthesis technique of 4-（4＇-cyano-2＇-fluorophenoxy） phenol is reviewed. 4-hydroxyanisole and 3, 4-difluorobenzonitrile is used as the major starting materials to obtain 4-（4＇-eyano-2＇-fluorophenoxy） anisole. Then 4-（4＇-cyano-2＇-fluorophenoxy） phenol is obtained by deoxidizing 4-（4＇-cyano-2＇- fluorophenoxy） anisole with BBr3. Its chemical structure is characterized by IR, ^1H-NMR and mass spectrum. The total yield is 64% and the purity is 95.2%. Thereby this method overcomes the disadvantages of small amount of production and low yield.

关 键 词：3 4-二氟苯腈 对羟基苯甲醚 4-(2'-氟-4'-氰基苯氧基)苯甲醚 4-(2'-氟-4'-氰基苯氧基)苯酚 合成 

分 类 号：TQ243.1[化学工程—有机化工]